Anti-obesity Effects of SBY-III in High Fat Diet-Fed Obese Rats Continued by High Fat Diet and Regulated by Normal Diet

SBY-III이 비만 및 비만 후 식이조절 흰쥐에 미치는 영향

  • Woo, Kyung-Ha (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Chung, Seok-Hee (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Jong-Su (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Sung-Soo (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Shin, Hyun-Dae (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University)
  • 우경하 (경희대학교 한의과대학 한방재활의학과교실) ;
  • 정석희 (경희대학교 한의과대학 한방재활의학과교실) ;
  • 이종수 (경희대학교 한의과대학 한방재활의학과교실) ;
  • 김성수 (경희대학교 한의과대학 한방재활의학과교실) ;
  • 신현대 (경희대학교 한의과대학 한방재활의학과교실)
  • Received : 2005.03.29
  • Accepted : 2005.04.22
  • Published : 2005.04.30
  • 69 0


Abstract

Objectives : This experimental study was designed to investigate the effect of SBY-III extract on the weight, cell size of epididymal fat-pad, fat accumulation area in liver, serum lipid level and UCP1 mRNA in brown adipose tissue of high fat diet-fed obese rats continued by high fat diet and regulated by normal Diet. Methods : The body weight gain, weight of the internal organs(epididymis, liver, brown adipose tissue), insulin, triglyceride, total cholesterol, total lopod, free fatty acid, expression of UCP1 mRNA were measured in high fat diet-fed obese rats continued by high fat diet and regulated by normal diet. The experimental study are divided into exp-I and exp-II. Each study was administered normal diet, high fat diet and SBY-III according to each situation. Normal group is normal diet for 8 weeks. Exp-I are divided into control group(high fat diet for 8 weeks) and sample group(high fat diet for 8 weeks and SBY-III for last 2 weeks). Exp-II are divided into control group(high fat diet for 6 weeks and normal diet for 2 weeks) and sample group(high fat diet for 6 weeks and normal diet with SBY-III for 2 weeks). These were then compared mutually. Results : 1. Irrespective of diet control, sample group taken SBY-III showed the more effective decrease of weight gain than control group and diet control-fed sample group with SBY-III showed the more effective decrease of weight loss including weight gain than control group. 2. Irrespective of diet control, sample group taken SBY-III showed the more effective decrease cell size of epididymal fat-pad, fat accumulation area in liver than control group. 3. Non diet control-fed sample group taken SBY-III showed the more effective decrease of serum triglyceride, total lipid, free fatty acid than control group and diet control-fed sample group taken SBY-III showed the decrease of serum triglyceride, free fatty acid than control group. 4. Only diet control-fed sample group taken SBY-III showed the decrease of UCP1 volume. Conclusions : These results shows that SBY-III has effects on anti-obesity, especially keeping pace with diet control.

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