Inhibitory Effect of Acute Pancreatitis in Rats by Patrinia Scabiosaefolia

급성췌장염 유발된 흰쥐에 대한 패장의 억제 효과

  • Lee, Joon-Suk (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Jung, Sang-Pil (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Kil, Eun-Young (Dept. of Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Lee, Su-Kyung (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Kwon, Young-Dal (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Song, Yung-Sun (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Won-Kwang University)
  • 이준석 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 정상필 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 길은영 (원광대학교 전주한방병원 재활의학과) ;
  • 이수경 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 권영달 (원광대학교 한의과대학 한방재활의학과교실) ;
  • 송용선 (원광대학교 한의과대학 한방재활의학과교실)
  • Received : 2004.12.23
  • Accepted : 2005.01.20
  • Published : 2005.01.30


Objectives : Patrinia scabiosaefolia (PS) has long been as a remedy for treating infectious diseases in Korea. In the present experiments, the author examined the effects of PS on the cholecystokinin-octapeptide (CCK)-induced pancreatitis (AP) in rats. Methods : Male Wister rats weighing 200 to 250 g were divided into two group. Normal untreated group, in treatment with PS group; PS was administered orally, followed by $75{\mu}g/kg$ CCK subcutaneously three times, after 1, 3 and 5 h. This whole procedure was repeated for 5 days. In treatment with saline group, the protocol was the same as in treatment group with PS. The author determined the pancreatic weight/body weight ratio, the levels of pancreatic heat shock proteins(HSP)60, HSP72 and the secretion of pro-inflammatory cytokines. Results and Conclusion : PS was significantly decreased the pancreatic weight/body weight ratio in CCK-induced AP. PS increased HSP60 and HSP72 compared with CCK-induced AP. Additionally, the secretion of tumor necrosis factor(TNF)-${\alpha}$, interleukin(IL)-$1{\beta}$ and IL-6 the levels of amylase and lipase were lower than that of saline. These results suggest that PS may has a inhibitory effect against CCK-induced AP.


  1. 中藥大辭典 江蘇新醫學院(編)
  2. 經史證類備急本草 唐愼微
  3. 臨床本草學 辛民敎 (編著)
  4. 漢英常用中藥手冊 歌明主(編)
  5. 和漢藥物學 高木敬次郞
  6. Chem Pharm Bull. v.36 no.11 Phytochemical studies of seeds of medicinal plants. I. Two Sul-fated Triterpenoid Glycosides, sulfapatrinosides I and II, from seeds of patrinia scabiosaefolia FISCHER. Inada, A.;Yamada, M.;Murta, H.;Kobayashi, M.;Toya, H.;Kato, Y.;Nakanishi, T.
  7. J Nat Prod v.60 A triterpenoid saponin from patrinia scabiosaefolia Kang, S.S.;Kim, J.S.
  8. Chem Pharm Bull. v.41 no.1 Phytochemical studies of seeds of medicinal plants. III. ursolic acid and oleanolic acid glycosides from seeds of patrinia sca-biosaefolia FISCHER Nakanashi, T.;Tanaka, K.;Murata, H.;Somekawa, M.;Inada, A.
  9. 원광대학교 박사학위논문 lipopopysaccharide에 의해 유발된 발열에 있어서 패장의 해열효과 송채석
  10. 원광대학교 석사학위논문 남성호르몬 비의존형 전립선 암세포에서 패장 추출물의 세포고사유도효과 황태옥
  11. 원광대학교 석사학위논문 전립선 암세포의 패장추출물의 세포고사유도효과 김인규
  12. 원광대학교 석사학위논문 포공영의 급성 췌장염 억제 효과 임병철
  13. 漢藥臨床應用 李尙仁;辛民敎
  14. Physiol Rev. v.72 Mammalian stress response: cell physiology; structure/function of stress proteins;and implications for medicine and disease Welch, W.J.
  15. Acute pancreatitis Soergel, K.H.;Sleisenger, M.H.(ed.);Fordtran, J.S.(ed.)
  16. 경희한의대논문집 v.14 황화패장과 백화패장이 항암작용 및 면역반응에 미치는 영향 박춘혁;김광호
  17. Int J Hyperthermia. v.17 Water immersion pretreatment decreases pro-inflam-matory cytokine production in cholecystokinin-octapeptide-induced acute pancreatitis in rats:possible role of HSP72 Rakonczay, Z. Jr.;Takacs, T.;Mandi, Y.;Ivanyi, B.;Barga, I.;Papai, G.;Boros, I.;Lonovics, J.
  18. Acta. Chem Scand. v.15 On the biological activity and amino acid composition of secretion Jorpes, J.E.;Mutt, V.
  19. Experientia. v.24 Synthetic peptides related to cerulein Anastasi, A.;Bernad, I.;Bertaccini, G.
  20. Gastroenterlogy v.55 The isolation and chemistry of secretion and cholecystokinin Jorpes, J.E.
  21. J Nucl Med. v.32 Cholecystokinin cholescintigraphy:Detection of abnormal gallbladder motor fuction in patients with chronic acalculous galbladder diseases Fink-Bennet.;DeRidder, P.;Kolozsi, W.Z.;Gordon, R.;Jaros, R.
  22. Semin Nucl Med. v.21 Augmented cholescintigraphy: Its role in detecting acute and chronic disorders of the hepatobiliary tree Fink-Bennet.
  23. Gastroenterology v.80 Radionuclide ejection fraction: A tecknique for quantitative analysis of motor function of the human gallbladder Krishnamurthy, G.T.;Bobba, V.R.;Kingston, E.
  24. Annu. Rev. Biochem. v.55 The heat-shock response Lindquist, S.
  25. Int J Biochem. v.26 Induction of heat shock protein and prevention of cerulein-induced pancreatitis by water-im-mersion stress in rats Otaka, M.;Itoh, H.;Kuwabara, T.;Zeniya, A.;Fujimori, S.;Otani, S.;Tashima, Y.;Masamune, O.
  26. Dig Dis Sci. v.42 Differential induction of HSP60 and HSP72 by different stress situations in rats Otaka, M.;Okuyama, A.;Otani, S.;Jin, M.;Okayama, A.;Itoh, S.;Iwabuchi, A.;Sasahara, H.;Itoh, H.;Tashima, Y.;Komatsu, M.;Masamune, O.
  27. Gastroenterology v.111 Hyperthermia induces heat shock protein expression and protection against cerulein-induced pancreatitis in rats Wagner, A.C.;Weber, H.;Jonas, L.;Nizz, H.;Strowski, M.;Fiedler, F.;Printz, H.;Steffen, H.;Goke, B.
  28. Pancreas v.21 Hyperthermia induces heat-shock protein expression; reduces pancreatic injury; and improves survival in necrotizing pancreatitis Grise, K.;Kim, F.;McFadden, D.
  29. Gastroenterology v.119 Water immersion stress induces heat shock protein 60 expression and protects against pancreatitis in rats Lee, H.S.;Bhagat, L.;Frossard, J.L.;Hietaranta, A.;Singh, V.P.;Steer, M.L.;Saluja, A.K.
  30. Am J Physiol Gastrointest Liver Physiol. v.280 Effect of hyperthermia on NF-B binding activity in cerulein-induced acute pancreatitis Frossard, J.L.;Pastor, C.M.;Hadengue, A.
  31. Am J Physiol. v.273 Caerulein pancreatitis increases mRNA but reduces protein levels of rat pancreatic heat shock proteins Strowski, M.Z.;Sparmann, G.;Weber, H.;Fiedler, F.;Printz, H.;Jonas, L.;Goke, B.;Wagner, A.C.
  32. Clin Chem. v.39 Clinical and analytical evaluation of a continuous enzymatic method for measuring pancreatic lipase activity Panteghini, M.;Pagani, F.;Bonora, R.
  33. Am J Surg. v.175 The role of cytokines in the path-ogenesis of acute pancreatitis Norman, J.
  34. J Surg Res. v.99 Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis Lane, J.S.;Todd, K.E.;Gloor, B.;Chandler, C.F.;Kau, A.W.;Ashley, S.W.;Reber, H.A.;McFadden, D.W.
  35. 대한소화기학회 연수강좌 급성췌장염의 발생기전 김창덕
  36. Gut. v.34 Role of inteleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis Heath, D.I.;Cruickshank, A.;Gudgeon, M.;Jehanli, A.;Shenkin, A.;Imrie, C.W.
  37. Gut. v.33 Endotoxaemia and serum tumour necrosis factor as prognostic markers in severe acute pancreatitis Exley, A.R.;Leese, T.;Holliday, M.P.;Swann, R.A.;Cohen, J.
  38. J Clin Chem Clin Biochem. v.28 Diagnostic utility of a new monoclonal antibody pancreatic isoamylase assay in chronic pancreatic diseases Panozzo, M.P.;Basso, D.;Fabris, C.;Faggian, D.;Meggiato, T.;Plebani, M.;Del, Favero G.;Fogar, P.;Scalon, P.;Ferrara, C.