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Relationship of Early Lactation and Bovine Somatotropin to Water Metabolism and Mammary Circulation of Crossbred Holstein Cattle

Maksiri, W.;Chanpongsang, S.;Chaiyabutr, N.

  • Received : 2005.02.01
  • Accepted : 2005.05.31
  • Published : 2005.11.01

Abstract

The study was carried out to evaluate the effect of exogenous bovine somatotropin on water metabolism in relation to mammary function in early lactation of crossbred Holstein cattle. Ten, 87.5% crossbred Holstein cattle were divided into two groups of 5 animals each. At day 60 of lactation, the control group was given placebo while animals in the experimental group were given recombinant bovine somatotropin (rbST) by subcutaneous injection with 500 mg of rbST (14-days prolonged-release rbST). In rbSTtreated animals, milk yield increased 19.8%, which coincided with a significant increase in water intake (p<0.01), while DM daily intake was not different when compared to the control animals. Water turnover rate as absolute values significantly increased (p<0.05), while the biological half-life of water did not change in rbST-treated animals. Total body water (TBW) and total body water space (TOH) as absolute values significantly increased (p<0.01) in rbST-treated animals, while it was decreased in the control animals. Absolute values of empty body water (EBW) markedly increased (p<0.05), which was associated with an increase in the extracellular fluid (ECF) volume. Absolute values of plasma volume and blood volume were also significantly increased (p<0.05) in rbST-treated animals. The increase in mammary blood flow in rbST-treated animals was proportionally higher than an increase in milk production. The plasma IGF-1 concentration was significantly increased (p<0.01) in rbST-treated animals when compared with those of control animals during the treatment period. Milk fat concentration increased during rbST treatment, while the concentrations of both protein and lactose in milk were not affected. The present results indicate that rbST exerts its effect on an increase in both TBW and EBW. An increased ECF compartment in rbST-treated animals might partly result from the decrease in fat mass during early lactation. The action of rbST on mammary blood flow might not be mediated solely by the action of IGF-1 for increase in blood flow to mammary gland. An elevation of body fluid during rbST treatment in early lactation may be partly a result of an increase in mammary blood flow in distribution of milk precursors to the gland.

Keywords

rbST;Mammary Blood Flow;Total Body Water;Early Lactation;Cross Bred Holstein Cattle

References

  1. Akers, R. M. 1985. Lactogenic hormones: binding sites, mammary growth, secretory cell differentiation and milk biosynthesis in ruminants. J. Dairy Sci. 68:501-519. https://doi.org/10.3168/jds.S0022-0302(85)80849-3
  2. Chaiyabutr, N., S. Komolvanich, S. Sawangkoon, S. Preuksagorn and S. Chanpongsang. 1997. The regulation of body fluid and mammary circulation during late pregnancy and early lactation of crossbred Holstein cattle feeding on different types of roughage. J. Anim. Physiol. Anim. Nutr. 77:167-179.
  3. Chaiyabutr, N., S. Preuksagorn, S. Komolvanich and S. Chanpongsang. 2000. Plasma levels of hormones and metabolites as affected by the forages type in two different types of crossbred Holstein cattle. Asian-Aust. J. Anim. Sci. 13:1359-1366.
  4. Linzell, J. L. 1974. Mammary blood flow and methods of identifying and measuring precursors of milk. In: Lactation 1., (Ed B. L. Larson and V. R. Smith). N.Y. and London: Academic Press. pp. 143-225.
  5. Chaiyabutr, N., S. Komolvanich, S. Thammacharoen and S. Chanpongsang. 2004. The plasma level of insulin-like growth factor-1 (IGF-1) in relation to mammary circulation and milk yield in two different types of crossbred Holstein cattle. Asian-Aust. J. Anim. Sci. 17(3):343-348.
  6. McDowell, G. H., J. M. Gooden, D. Leenanuruksa, M. Jois and A. W. English. 1987. Effects of exogenous growth hormone on milk production and nutrient uptake by muscle and mammary tissues of dairy cows in mid-lactation. Aus. J. Biol. Sci. 40:295.
  7. Tele, F. F., K. Young and J. W. Stull. 1978. A method for rapid determination of lactose. J. Dairy Sci. 61:506-508.
  8. Mepham, T. B., S. E. Lawrence, A. R. Peters and I. C. Hart. 1984. Effects of exogenous growth hormone on mammary function in lactating goats. Horm. Metab. Res. 16:248.
  9. AOAC. 1984. Official methods of analysis. 12th Ed. Association of Official Analytical Chemists, Washington, DC.
  10. Vaughan, B. E. and E. A. Boling. 1961. Rapid assay procedures for tritium-labelled water in body fluid. J. Lab. Clin. Med. 57:159-164.
  11. Capuco, A. V., D. L. Wood, R. Baldwin, K. Mcleod and M. J. Paape. 2001. Mammary cell number, proliferation, and apoptosis during a bovine lactation: Relation to milk production and effect of bST. J. Dairy Sci. 84:2177-2187.
  12. Chaiyabutr, N., S. Preuksagorn, S. Komolvanich and S. Chanpongsang. 1999. Comparative study on the regulation of body fluids and mammary circulation at different stages of lactation in crossbred Holstein cattle feeding on different types of roughage. J. Anim. Physiol. Anim. Nutr. 81:74-84.
  13. Shipley, R. A. and R. E. Clark. 1972. Tracer methods for in vivo kinetics. New York, NY: Academic Press.
  14. Van Soest, P. J. and L. B. Robertson. 1980. Systems of analysis for evaluating fibrous feeds. In: Standardization of Analytical Methodology for Feeds (Ed. W. J. Pigden, C. C. Balch and M. Graham). Proceeding of a Workshop Help in Ottawa, Canada, pp. 49-60.
  15. Janssen, Y. J. H., P. Deurenberg and F. Roelfsema. 1997. Using dilution techniques and multifrequency bioelectrical impedance to assess both total body water and extracellular water at baseline and during recombinant human growth hormone (GH) treament in GH- deficient adults. J. Clin. Endocrin. Metab. 10:3349-3355.
  16. Mishra, A. and D. C. Shukla. 2004. Effect of recombinant bovine somatotropin (Boostin-250) on blood metabolites and milk yield of lactating buffaloes. Asian-Aust. J. Anim. Sci. 17(9):1232-1235.
  17. Tanwattana, P., S. Chanpongsang and N. Chaiyabutr. 2003. Effects of exogenous bovine somatotropin on mammary function of late lactating crossbred Holstein cows. Asian-Aust. J. Anim. Sci. 16:88-95.
  18. Akers, R. M. 1985. Lactogenic hormones: binding sites, mammary growth,secretory cell differentiation and milk biosynthesis in ruminants. J. Dairy Sci. 68:501-519. https://doi.org/10.3168/jds.S0022-0302(85)80849-3
  19. Clunie Harvey, W. and H. Hill. 1967. Butter-fat percentage. In: Milk Production and Control, 4th edition, London, H.K. Lewis and Co. Ltd., pp. 519-520.
  20. Snedecor, G. W. and W. G. Cochran. 1989. Statistical methods.9th edn. The Iowa state Univ. Press, Ames, Iowa.
  21. Woodford, S. T., M. R. Murphy and C. L. Davis. 1984. Water dynamics of dairy cattle as affected by initiation of lactation and feed intake. J. Dairy Sci. 67:2336-2343.
  22. Hanwell, A. and M. Peaker. 1977. Physiological effects of lactation on the mother. In: Comparative Aspects of Lactation (Ed. M. Peaker). Symposia of the Zoological Society of London 41. Academic Press, London. pp. 279-312.
  23. Etherton, T. D. and D. E. Bauman. 1998. Biology of somatotropin in growth and lactation of domestic animals. Phys. Rev. 78:745-761.
  24. Gulay,M. S., A. N. Garcia, M. J. Hayen, C. J. Wilcox and H. H. Head. 2004. Responses of Holstein cows to different bovine somatotropin (bST) treatments during the transition period and early lactation. Asian-Aust. J. Anim. Sci. 17(6):784-793.
  25. Davis, S. R., R. J. Collier, J. P. McNamara, H. H. Head and W.Sussman. 1988. Effects of thyroxine and growth hormone treatment of dairy cows on milk yield, cardiac output and mammary blood flow. J. Anim. Sci. 66:70-79.
  26. Murphy, M. R. 1992. Symposium: Nutritional factors affecting animal water and waste quality. J. Dairy Sci. 75:326-333. https://doi.org/10.3168/jds.S0022-0302(92)77768-6
  27. Peel, C. J. and D. E. Bauman. 1987. Somatotropin and lactation. J. Dairy Sci. 70:474- 486.
  28. West, J. W., K. Bondari and J. C. Jhonson. 1990. Effects of bovine somatotropin on milk yield and composition, body weight, and condition score of Holstein and Jersey cows. J. Dairy Sci. 73:1062-1068.
  29. Sechen, S. J., F. R. Dunshea and D. E. Bauman. 1990. Somatotropin in lactating cows: effect on response to epinephrine and insulin. Am. J. Physiol. 258:E582-588.