The assessment of anesthetic depth by quantitative electroencephalography in intravenous anesthesia by intermittent bolus injection

간헐적 일시 정맥주사 마취에서 정량적 뇌파분석을 이용한 마취 심도의 평가

  • Lee, Soo-Han (College of Veterinary Medicine, Konkuk University) ;
  • Bae, Chun-Sik (College of Veterinary Medicine, Biotechnology Research Institute, Chonnam National University) ;
  • Noh, Gyu-Jeong (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Bae, Kyun-Seop (Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jin-Young (College of Veterinary Medicine, Konkuk University) ;
  • Chung, Byung-Hyun (College of Veterinary Medicine, Konkuk University)
  • 이수한 (건국대학교 수의과대학) ;
  • 배춘식 (전남대학교 수의과대학 및 생물공학연구소) ;
  • 노규정 (울산의대 서울아산병원 마취통증의학교실) ;
  • 배균섭 (울산의대 서울아산병원 임상약리학교실) ;
  • 김진영 (건국대학교 수의과대학) ;
  • 정병현 (건국대학교 수의과대학)
  • Accepted : 2005.03.07
  • Published : 2005.03.25


To assess anesthetic depth using quantitative electroencephalography (q-EEG), we recorded processed EEG (raw EEG) till 100 minutes in beagle dogs anesthetized for 60 minutes with tiletamine/zolazepam (n=5, TZ group), xylazine/ketamine (n=5, XK group) and propofol (n=5, PI group) by intermittent bolus injection. Raw EEG was converted into 95% spectral edge frequency (SEF) and median frequency (MF) through fast fourier transformation (FFT) method. 95% SEF value of TZ group was significantly higher (p<0.05) than the XK group from 10 minutes to 100 minutes. 95% SEF value of PI group was significantly higher (p<0.05) than the XK group from 10 minutes to 40 minutes, and significantly low (p<0.05) than XK group at 90 and 100 minutes. MF was significantly higher (p<0.05) in TZ group from 60 minutes to 100 minutes. Based on these results, using dissociative agent with ${\alpha}_2$-adrenergic agent is more potent in CNS depressed than using dissociative agent alone, and low doses of propofol has a disinhibitory effect on CNS.



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