The effect of green tea on ultraviolet B-induced sunburn cell production in the skin of hairless mouse

자외선 B 조사 hairless 마우스에서 일광화상세포 발생 억제에 대한 녹차의 효과

  • Kim, Sung-ho (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Se-ra (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Hae-june (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Jin-hee (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Yu-jin (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Jong-choon (College of Veterinary Medicine, Chonnam National University) ;
  • Jang, Jong-sik (Department of Animal Science, Sangju National University) ;
  • Jo, Sung-kee (Food Irradiation Team, Korea Atomic Energy Research Institute)
  • 김성호 (전남대학교 수의과대학) ;
  • 김세라 (전남대학교 수의과대학) ;
  • 이해준 (전남대학교 수의과대학) ;
  • 이진희 (전남대학교 수의과대학) ;
  • 김유진 (전남대학교 수의과대학) ;
  • 김종춘 (전남대학교 수의과대학) ;
  • 장종식 (상주대학교 축산학과) ;
  • 조성기 (한국원자력연구소 방사선이용연구부)
  • Accepted : 2005.02.24
  • Published : 2005.03.25

Abstract

In this study we assessed the influences of ultraviolet (UV) light B radiation on epidermal cells by apoptotic sunburn cell (SBC) and the effect of green tea treatment on the inhibition of SBC formation in SKH1-hr mouse. The extent of changes following $200mJ/cm^2$ (0.5 mW/sec) was studied at 0, 3, 6, 12, 18, 24, 30 or 36 hours after exposure. SBCs were recognized by 3 hours after irradiation. There was tendency to increase from 3 hours to 24 hours and decrease from then to 36 hours after irradiation. The mice that received 0, 25, 50, 100, 200, 400 or $800mJ/cm^2$ of UVB were examined 24 hours after irradiation. The SBCs were induced as the radiation dose increases from 0 to $200mJ/cm^2$. A further increase of radiation dose has little further effect. The frequency of UVB ($200mJ/cm^2$)-induced SBC formation was reduced by intraperitoneal injection of green tea extract (p<0.01).

Acknowledgement

Supported by : 과학기술부

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