Antibacterial effects of Terminaliae chebula extract against major pathogens and methicillin-resistant Staphylococcus aureus (MRSA) from bovine mastitis milk

가자(Terminaliae chebula) 추출물의 젖소 유방염 주요 원인체 및 메치실린내성 황색포도상구균(MRSA)에 대한 항균효과

  • Accepted : 2005.01.09
  • Published : 2005.03.25


Resistance to antibiotics is a problem all over the world, and this problem also is so extended in veterinary fields. Therefore, this study aimed to find out the antibacterial substances from natural medicinal herbs against bovine mastitis pathogens, especially methicillin-resistant Staphylococcus aureus (MRSA). Among seventy two medicinal herbs, Terminaliae chebula extract showed antimicrobial effect against MRSA isolated from mastitis milk in cow and patient in human. However, Terminaliae chebula extract didn't show antibacterial effects on various strains including other contagious and environmental pathogens related with mastitis of dairy cows.


  1. 곽이성, 양재원, 이광승. 일부 병원성 미생물에 대해 항균활성을 보이는 생약의 탐색. 한국식품위생학회지 1993, 8, 141-145
  2. 김경임, 남주형, 권태완. 오미자 일반성분, 유기산 및 anthocyanin 색소에 관하여. 한국식품과학회지 1973, 5, 178-182
  3. 김태철, 이기동, 윤형식. 오배자(Rhus japonica Linne) methanol 추출물의 항산화효과. 한국식품위생학회지 1992, 7, 107-112
  4. 남용옥, 김선숙, 장유정. Streptococcus mutans JC-2의 우식활성에 마치는 가자의 효과. 대한구강보건학회지 1995, 19, 495-503
  5. 오상룡, 김성수, 민병용, 정동효. 구기자(Lycium chinensis Miller), 당귀(Angelica acutiloba Kitag), 오미자(Schizandra chinensis Bailon), 오갈피(Acanthopanax sessiliflorum Seeman) 추출물의 유리당, 유리아미노산, 유기산 및 타닌의 조성. 한국식품과학학회지 1990, 22, 76-81
  6. 이상인. 한약임상응용, pp. 392-393, 성보사, 서 울 1990
  7. 정민섭, 신민교. 향약생약 대사전 (식물편). 영림사 1990
  8. 조재용, 최일, 황의경. Escherichia coli에 대한 한약재 추출물의 항균활성. 대한수의학회지 2003, 43, 625-631
  9. 최원균, 노용철, 황성연. 자몽종자추출물과 폴리리신 혼합물의 식품부패균에 대한 항균효과. Korean J Dietary Culture 2000, 15, 9-15
  10. Aarestrup FM, Dangler CA, Sordillo LM. Prevalence of coagulase gene polymorphism in Staphylococcus aureus isolates causing mastitis. Can J Vet Res 1995, 59, 124-128
  11. Bauer AW, Kirby M, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966, 45, 493
  12. Choi MY, Choi EJ, Lee E, Rhim TJ, Cha BC, Park HJ. Antimicrobial activities of pine needle (Pinus densiflora Seib et Zucc.) extract. Korean J Appl Microbial Biotechnol 1997, 25, 293-297
  13. Gilmour A, Harvey J. Staphylococci in milk and milk products. Soc Appl Bacteriol Symp Ser 1990, 19, 147s-166s
  14. Gruet P, Maincent P, Berthelot X, Kaltasatos V. Bovine mastitis and intramammary drug delivery. review and perspectives. Adv Drug Deliv Rev 2001, 50, 245-259
  15. Kang SK, Kim D, Park SK. Effects of antimicrobial of Leaf Mustard (Brassica juncea) extract on compositions and leakage of cellular materials in Escherichia coli and Staphylococcus aureus. J Korean Soc Food Nutr 1995, 24, 280-285
  16. Kim SJ. Screening and characteristics of antimicrobial activity in oriental medicines. Kyungsan National Univ PhD' Dissertation 1995
  17. Lee BW, Shin DH. Screening of natural antimicrobial plant extract on food spoilage microorganisms. Korean J Food Sci Technol 1991, 23, 200-204
  18. Lee SH, Im YS. Effects of mija (Schizandra chinensis) extract on the growth of lactic acid bacteria isolated from kimchi. Korean J Appl Microbiol Biotechnol 1997, 25, 224-228
  19. Mok SJ, Park UY, Kim YM, Chang DS. Effects of solvents and extracting condition on the antimicrobial activity of salviae miltiorrhizae radix (salvia miltiorrhiza) extract. J Korean Soc Food Nutr 1994, 23, 1001-1007
  20. Musser JM, Schlievert PM, Chow AW, Ewan P, Kreiswirth BN, Rosdahl VT, Naidu AS, Witte W, Selander RK. A single clone of staphylococcus causes the majority of cases of toxic shock syndrome. Proc Natl Acad Sci USA 1990, 87, 225-229
  21. Park UY, Chang DS, Cho HR. Antimicrobial effect of lithospermi radix (lithospermum erythrorhizon) extract. J Korean Soc Food Nutr 1992, 21, 97
  22. Park UY, Chang DS, Cho HR. Screening of antimicrobial activity for medicinal herb extracts. J Korean Soc Food Nutr 1992, 21, 91-96
  23. Park UY, Chang DS, Cho HR. Screening of antimicrobial activity for medicinal herb extracts. J Korean Soc Food Sci Nutr 1992, 21, 91-98
  24. Yang MS, Ha YL, Nam SH, Choi SU, Jang DS. Screening of domestic plants with antibacterial activity. Agri Chem Biotech 1995, 38, 584-589
  25. Yeo SG, Ahn CW, Kim IS, Park YB, Park YH, Kim SB. Antimicrobial effect of tea extracts from green tea, oolong tea and black tea. J Korean Soc Food Nutr 1995, 24, 293-298