DOI QR코드

DOI QR Code

Effects of Dietary Supplementation with Branched-chain Amino Acids (BCAAs) during Nursing on Plasma BCAA Levels and Subsequent Growth in Cattle

  • Li, J.Y. (Research Unit for Animal Life Science, Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ;
  • Suzuki, K. (Research Unit for Animal Life Science, Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ;
  • Koike, Y. (Research Unit for Animal Life Science, Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ;
  • Chen, D.S. (Research Unit for Animal Life Science, Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ;
  • Yonezawa, T. (Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ;
  • Nishihara, M. (Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo) ;
  • Manabe, N. (Research Unit for Animal Life Science, Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo)
  • Received : 2004.11.01
  • Accepted : 2005.04.22
  • Published : 2005.10.01

Abstract

To determine the effects of short-term dietary supplementation of branched-chain amino acids (BCAAs) during nursing (from 3 to 28 days of age) on plasma BCAA levels and subsequent growths in cattle, 12 nursing male Holstein calves, randomly assigned to control and treatment groups (n = 6 in each group), orally received a daily supplement of essential BCAAs (2 g/kg body weight/day; 1:1:1 of valine, leucine and isoleucine) or not. The plasma BCAA levels increased linearly after the administration. During the treatment period, average daily gain (ADG) was lower in the treatment group (0.43${\pm}$0.07 kg/day) than the controls (0.71${\pm}$0.07 kg/day, p<0.05). However, at 2 months of age, ADG was significantly higher in the BCAA-treated group (1.16${\pm}$0.26 kg/day vs. 0.51${\pm}$0.06 kg/day, p<0.05). Furthermore, at age 8, 9 and 10 month, ADG in the treated group (1.35${\pm}$0.23, 1.46${\pm}$0.07 and 1.60${\pm}$0.16 kg/day, respectively) showed a linear increase and was significantly higher than that in the control group (0.88${\pm}$0.14, 0.70${\pm}$0.21 and 1.11${\pm}$0.11 kg/kg, respectively, p<0.05). Overall, ADG was 15.6% higher in the treatment group (1.26${\pm}$0.05 kg vs. 1.09${\pm}$0.04 kg; p<0.05). The final body weight at slaughter was 14.8% higher in the treatment group (759.5${\pm}$17.7 kg vs. 661.7${\pm}$21.2 kg, p<0.01). Thus, the supplementation of BCAAs during nursing improves ADG and carcass weight in cattle and is a useful husbandry technique for beef cattle.

Keywords

Branched-chain Amino Acid;Plasma Concentration;Average Daily Gain;Carcass Weight;Cattle

Acknowledgement

Supported by : Creative Scientific Research

References

  1. Enzi, G., E. M. Inelmen, F. Caretta, F. Villani, V. Zanardo and F. D. Debiasi. 1980. Development of adipose tissue in newborns of gestational-diabetic and insulin-dependent diabetic mothers. Diabetes 29:100-104.
  2. Persson, B., H. Pschera, N. O. Lunell, J. Barley and K. A. Gumaa. 1986. Amino acid concentration in maternal plasma and amniotic fluid in relation to fetal insulin secretion during the last trimester of pregnancy in gestational and type I diabeticwomen and women with small-for-gestational age infants. Am. J. Periat. 3:98-103.
  3. Rose, W. C. 1957. The amino acid requirement of adult man. Nutrit. Abst. Rev. 27:631-647.
  4. Tews, J. K., H. Joyce, J. J. Repa and A. E. Harper. 1990. A branched-chain amino acids analog affecting feeding behavior of rats. Pharmacol. Biochem. Behav. 35:911-921.
  5. Hong, S. O. and D. K. Layman. 1984. Effects of leucine on in vitro protein synthesis and degradation in rat skeletal muscles. J. Nutrit. 114:1204-1212.
  6. Milner, R. D., M. A. Ashworth and A. J. Barson. 1972. Insulin release from human fetal pancreas in response to glucose, leucine and arginine. J. Endocrine 52:497-505.
  7. Harper, A. E., N. J. Benevenga and R. M. Wohlhueter. 1970. Effects of ingestion of disproportionate amounts of amino acids. Physiol. Rev. 50:428-558.
  8. Martorell, R., A. D. Stein and D. G. Schroeder. 2001. Early nutrition and later adiposity. J. Nutrit. 131:874-880.
  9. Richmond, R. J. and R. T. Berg. 1982. Relative growth patterns of individual muscles in the pig. Canadian J. Anim. Sci. 62:575-586.
  10. Metzger, B. E., R. L. Phelps, N. Freinkel and I. A. Navickas. 1980. Effect of gestational diabetes on diurnal profiles of plasma glucose, lipids, and individual amino acid. Diabet. Care 3:402-409.
  11. Okeet, B. O., S. C. Loerch and L. E. Deetz. 1986. Effects of rumen-protected methionine and lysine on ruminant performance and nutrient metabolism. J. Anim. Sci. 62:1011-12.
  12. Whitaker, R. C. and W. H. Dietz. 1998. Role of the prenatal environment in the development of obesity. J. Pediat. 132:768-776.
  13. Whitelaw, A. 1977. Subcutaneous fat in newborns infant of diabetic mothers: an indication of quality of diabetic control. Lancet 1:15-18.
  14. Buse, M. G. and D. A. Weigand. 1977. Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic rats. Biochim. Biophys. Acta 475:81-89.
  15. Bergen, W. G. and E. L. Potter. 1975. Effect of dietary protein level on plasma and tissue free amino acid concentrations in nursing lambs. J. Anim. Sci. 40:789-794.
  16. Buse, M. G., I. R. Cheema, M. Owens, B. E. Ledford and R. A. Galbraith. 1984. Muscle protein synthesis: regulation of a translational inhibitor. Am. J. Physiol. 246:510-515.
  17. Peng, Y., J. K. Tews and A. E. Harper. 1972. Amino acid imbalance, protein intake, and changes in rat brain and plasma amino acids. Am. J. Physiol. 222:314-319.
  18. Veresegyhazy, T., H. Febel and A. Rimanoczy. 2001. Absorption of leucine, alanine and lysine from the rumen. Acta Veter. Hung. 49:81-86.