Cytotoxic Phenylpropanoids from the Rhizomes of Alpinia galanga

  • NAM Joo-Won (College of Pharmacy, Ewha Womans University) ;
  • KIM Sun-Jack (College of Pharmacy, Ewha Womans University) ;
  • HAN Ah-Reum (College of Pharmacy, Ewha Womans University) ;
  • LEE Sang Kook (College of Pharmacy, Ewha Womans University) ;
  • SEO Eun-Kyoung (College of Pharmacy, Ewha Womans University)
  • Published : 2005.12.01


A bioassay-guided fractionation of the n-hexane and chloroform extracts of the rhizomes of Alpinia galanga led to the isolation of two active compounds, 1'S-1'-acetoxychavicol acetate (1) and p-coumaryl alcohol $\gamma$-O-methyl ether (2). 1'S-1'-acetoxychavicol acetate (1) exhibited significant cytotoxicity against all human cancer cell lines tested (A549; $IC_{50}$ 8.14, SNU 638; 1.27, HCTl16; 1.77, HT1080; 1.2, HL60; $IC_{50}$ 2.39 ${\mu}g/ml$), whereas p-coumaryl alcohol $\gamma$-O-methyl ether (2) showed selective cytotoxicity against the SNU638 cell ($IC_{50}$ = 1.62${\mu}g/ml$).


Alpinia galanga;Zingiberaceae;cytotoxicity, l'S-l'-acetoxychavicol acetate


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