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Study on the Anti-tumor Effects of Extracts from Lepista nuda Mushroom

민자주방망이버섯 추출물의 항암 효과에 대한 연구

  • Lee, Yang-Suk (Dept. of Herbal Biotechnology, Daegu Haany University) ;
  • Han, Joo-Young (Dept. of Food Cuisine and Nutrition, Daegu Haany University) ;
  • Joo, Eun-Yong (Dept. of Herbal Biotechnology, Daegu Haany University) ;
  • Shin, Seung-Ryeul (Dept. of Food Cuisine and Nutrition, Daegu Haany University) ;
  • Kim, Nam-Woo (Dept. of Herbal Biotechnology, Daegu Haany University)
  • 이양숙 (대구한의대학교 한방생명자원학과) ;
  • 한주영 (대구한의대학교 식품조리영양학부) ;
  • 주은영 (대구한의대학교 한방생명자원학과) ;
  • 신승렬 (대구한의대학교 식품조리영양학부) ;
  • 김남우 (대구한의대학교 한방생명자원학과)
  • Published : 2005.03.01

Abstract

This study was carried to investigate the inhibition effects of Lepista nuda mushroom extracts on the growth of the human cancer (HepG2, KATOⅢ, AGS) cells. The fraction Ⅰ of Lepista nuda mushroom extracts strongly inhibited to 71.4-91.8% for the growth of cancer cells. The growth of cancer HepG2, KATOⅢ and AGS cell which treated with 0.5 and 1㎎/mL of hot water fraction I was inhibited to 71.4% and 85.5%, 45.0% and 86.6%, 71.6% and 90.7% respectively. The growth of cancer cell HepG2, KATOⅢ and AGS which treated with 0.5 and 1㎎/mL of microwave fraction I was inhibited to 79.8% and 85.2%, 78.6% and 88.9%, 85.8% and 91.8%, respectively. The inhibition ratios of cancer cell growth were higher by microwave extracts than hot water extracts. And the more fraction were insoluble for water, the more inhibition ratios of cancer cell growth were lower.

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