Effects of Dietary Chitosan on Blood and Tissue Levels of Lead, Iron, Zinc, and Calcium in Lead Administered Rats

납 투여 흰쥐에서 혈액과 조직의 무기질 함량에 미치는 키토산의 섭취효과

  • Park, Joo-Ran (Dept. of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University) ;
  • Lee, Yeon-Sook (Dept. of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University)
  • 박주란 (서울대학교 식품영양학과, 생물과학연구소) ;
  • 이연숙 (서울대학교 식품영양학과, 생물과학연구소)
  • Published : 2005.03.01


Chitosan, which is a biopolymer, composed of glucosamine units linked by β-l, 4 glycoside bonds, is rich in shells of crustacean such as crabs and shrimps. We examined effects of dietary chitosan on blood and tissue levels of lead, iron, zinc and calcium in lead administered rats. Male Sprague-Dawley rats were divided into 4 groups (n=32). Basal diet group was fed 3% cellulose diet and lead administered groups were fed 0%, 3% and 5% chitosan diets, respectively for 8 wks. To lead administered groups, lead (20㎎/day) was given three times per week by oral injection. Blood, liver, kidney and femur were collected for lead, iron, zinc, and calcium analyses. There was no significant difference in weight gain and food intake among groups. Blood and femur lead levels were lower in lead administered groups fed 3% and 5% chitosan diets than in lead administered control (0% chitosan diet) group (p<0.05). Blood and liver levels of iron and zinc in lead administered group fed 5% chitosan diet were significantly lower than those in basal diet group (p<0.05), but those in lead administered group fed 3% chitosan diet were not significantly different with those in basal diet group. These results show that chitosan diets have beneficial effects on lowering the accumulation of lead, but high chitosan diet may have negative effects on mineral levels.



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