DOI QR코드

DOI QR Code

Effect of an Improving Agent for the Intestinal Function, a Poly Herbal Formulation (KTG075) on Secretion of Mucus

장기능개선제(KTG075)의 대장관내 점액(Mucus)분비에 미치는 영향

  • Published : 2005.03.01

Abstract

The maintenance of intestinal health is complex and relies on a delicate balance between the diet, the normal microflora and mucosa, including the digestive epithelium and overlying mucus layer. The colorectal mucosa is protected by a visco-elastic mucus gel formed by high molecular mass glycoproteins referred to as mucins. Abnormality of mucin have been identified with colorectal disease. Constipation increases with age, and is more common among women than men in all age groups, e.g. 10% of men and 20% of women in the USA. The aim of the present study was conducted to investigate that the effects of formulation KTG075 from edible plants on intestinal function on mucus secretion, were examined by loperamide-induced constipation method using Sprague Dawley male rats. Epithelial cells of colonic crypt contained more mucus in the KTG075 group compared with those of the control group and the thickness of the mucus layer stained with alcian blue was significantly thicker in KTG075 treated rats compared with in control rats. Mucus production of epithelial cells of crypt and mucus contents at fecal and mucosa surfaces were reduced by loperamide-induced constipation. These results indicates that a poly herbal formulation KTG075 accelerates evacuation and activated intestines.

References

  1. Silberberg A, Meyer FA. 1982. Structure and function of mucus. Adv Exp Med Biol 144: 53-74 https://doi.org/10.1007/978-1-4615-9254-9_6
  2. Corfield AP, Carrol D, Myerscouh N, Probert CSJ. 2001. Mucins in the gastrointestinal tract in health and disease. Front Biosci 6: 1321-1327 https://doi.org/10.2741/Corfield
  3. Corfield AP, Warren BF. 1996. Mucus glycoproteins and their role in colorectal disease. J Pathol 180: 8-17 https://doi.org/10.1002/(SICI)1096-9896(199609)180:1<8::AID-PATH596>3.0.CO;2-9
  4. Cepinskas G. 1993. Adaptive cytoprotection in the small intestine: role of mucus. Am J Physiol 264: 921-927
  5. Kirjavainen PV, Ouwehand AC, Isolauri E, Salminen SJ. 1998. The ability of probiotic bacteria to bind to human intestinal bacteria. FEMS Microbiol Lett 167: 185-189 https://doi.org/10.1111/j.1574-6968.1998.tb13226.x
  6. Ouwehand AC, Isolauri E, Kirijavainen VK, Salminen SJ. 1999. Adhension of four Bifidobacterium strains to human intestinal mucus from subjects in different age groups. FEMS Microbiol Lett 172: 61-64 https://doi.org/10.1111/j.1574-6968.1999.tb13450.x
  7. Tytgat KM, Buller HA, Opdam FJ, Kim YS, Einerhand AW, Dekker J. 1994. Biosynthesis of human colonic mucin: MUC2 is the prominent secretory mucin. J Castro 107: 1352-1363
  8. Tygat KMAJ, Vaa der waal JWG, Einerhand AWC, Buller HA, Dekker J. 1994. Quantitative analysis of MUC2 synthesis in ulcerative colitis. Biochem Biophys Res Commun 224: 397-405 https://doi.org/10.1006/bbrc.1996.1039
  9. Strugala V. 2003. Colonic mucin: methods of measuring mucus thickness. Proc Nutr Soc 62: 237-243 https://doi.org/10.1079/PNS2002205
  10. Loeschke K, Schmid T, Farack UM. 1989. Inhibition by loperamide of mucus secretion in the rat colon in vivo. Eur J Pharmacol 170: 41-46 https://doi.org/10.1016/0014-2999(89)90131-3
  11. Shimotoyodome A, Meguro S, Hase T, Tokimitsu I, Sakata T. 2000. Decreased colonic mucus in rats with loperamideinduced constipation. Comp Biochem Physiol 126: 203-211 https://doi.org/10.1016/S1095-6433(00)00194-X
  12. Shimotoyodome A, Meguro S, Hase T, Tokimitsu I, Sakata T. 2001. Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation. Digest Dis Sci 46: 1482-1489 https://doi.org/10.1023/A:1010644021888
  13. Pretlow TP, O'Riodan MA, Ptetlow TG, Stellato TA. 1992. Aberrant crypt in human colonic mucosa: putative preneo-plastic lesions. J Cell Biochem 16: 55-62