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Screening of Natural Plant Resources with Acetylcholinesterase Inhibition and Antioxidant Activity

천연 식물자원으로부터 Acetylcholinesterase 저해 및 항산화 활성 탐색

  • Kim, Dae-Ik (National Rural Resources Development Institute, NIAST) ;
  • Lee, Sung-Hyeon (National Rural Resources Development Institute, NIAST) ;
  • Hur, Eun-Young (National Rural Resources Development Institute, NIAST) ;
  • Cho, Soo-Muk (National Rural Resources Development Institute, NIAST) ;
  • Park, Hong-Ju (National Rural Resources Development Institute, NIAST)
  • 김대익 (농업과학기술원 농촌자원개발연구소) ;
  • 이성현 (농업과학기술원 농촌자원개발연구소) ;
  • 허은영 (농업과학기술원 농촌자원개발연구소) ;
  • 조수묵 (농업과학기술원 농촌자원개발연구소) ;
  • 박홍주 (농업과학기술원 농촌자원개발연구소)
  • Published : 2005.03.01

Abstract

This study was performed to investigate the effect of natural plant extracts on acetylcholinesterase (AChE) activity and the free radical scavenging activity. The methanolic extracts of plants were tested for AChE inhibitory activity using Ellman's colorimetric method in 96-welled microplates and antioxidant activity as the scavenging effect of 1, 1-diphenyl-2-picryl hydrazyl radical (DPPH). The results showed that AChE activities were inhibited (about 20-30%) in whole plant extract of Daucus carota var. sativa, Hypericum erectum and Fragaria yezoensis. AChE activities were inhibited (about 32-34%) in stems extract of Gingko biloba and leaves extract of Rhododendrondron yedoensa var. poukhanense. Fruit extract of Zanthoxylum schinifolium inhibited (about 18%) AChE activity. And the DPPH scavenging effects as antioxidant activity were similar to L-ascorbic acid in whole plant extract of Fragaria yezoensis and fruits extract of Comus officinalis.

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