Germanium Increases Alveolar Macrophage Engulfment of Apoptotic Neutrophils in Acute Lung Injury Induced by Endotoxin

내독소로 유도된 급성 폐 손상에서 게르마늄의 투여로 인한 호중구 세포사의 증가

  • Cho, Hyun-Gug (Department of Visual Optics, Kyungwoon University)
  • 조현국 (경운대학교 안경광학과)
  • Published : 2005.12.01

Abstract

Neutrophils that influx into the alveolar spaces from circulatory bloods play a important role in pathogenesis of acute lung injury. During the acute inflammatory phase, in order to investigate the acceleration of macrophage phagocytosis to the neutrophils is able to reduce the neutrophil-derived acute lung injury, endotoxemia was induced by insufflation of lipopolysaccharide intratracheally and organic germanium was injected intraperitoneally after endotoxin treatment. At 5 h after endotoxin treatment, lung weight and BAL protein concentration are significantly increased (p<0.001) compared to sham, and that was remarkedly decreased (p<0.001, p<0.01) by injection of germanium. In addition germanium treatment resulted to decreased the number of alveolar PMNs and to increase the percentage of engulfed neutrophils by alveolar macrophages. These observations indicate that organic germanium may have a role of reduction to neutrophil-derived acute lung injury in endotoxemia.

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