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Effect of Peking-Duck By-Product Extracts Supplemented with Medicinal Herbs on Serum Heavy Metal Levels and Blood Parameters of Rats Exposed to Lead and Mercury

한약재를 첨가한 오리부산물 추출액이 납과 수은에 노출된 흰쥐 혈청의 중금속 및 혈액지표에 미치는 영향

  • Park, Sung-Hye (Dept. of Herbal Resources, Professional Graduate of Oriental Medicine, Wonkwang University) ;
  • Shin, Eon-Hwan (Dept. of Hotel Culinary Arts, Ulsan College) ;
  • Park, Sung-Jin (Dept. of Bio-Food, Hallym College) ;
  • Ran, Jong-Hyun (Dept. of Herbal Resources, Professional Graduate of Oriental Medicine, Wonkwang University)
  • 박성혜 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 신언환 (울산대학교 호텔조리과) ;
  • 박성진 (한림성심대학 바이오식품과) ;
  • 한종현 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2005.04.01

Abstract

This experiment was planned to develop a functional supplement by food resources to prevent and lessen the deleterious effects caused by environmental pollutants such as polluted food, air, water and heavy metals. The goal of this study was to investigate the effects of peking-duck extracts supplemented with six kinds of medicinal herbs (DJ) on the intoxication of lead and mercury in rats. Sprague-Dawley rat weighing $150g\pm15g$ g, were randomly assigned to 5 groups, basal diet only (NCG), heavy metal without DJ injection (HCG), heavy metals and DJ (3 mg/mL) injection (HMLD), heavy metal and DJ (30 mg/mL) injection (HMMD), heavy metal and D] (300 mg/mL) injection (HMHD). Mecury (Hg) and lead (Pb) injected at the level of 50 ppm for 17 days. Also DJ oral feeding was continued for 31 days. The result of this study were as follows; Food intake and body weight gain in heavy metal administered groups were lower than those of control group (NCG). The activities of GOT, GPT and BUN level were significantly reduced in DJ-treated groups as compared to HCG. DJ was shown to suppress the accumulation of Hg and Pb in serum. The results suggest that DJ might have protective effect on Hg and Pb intoxication.

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