The Study on the Serum Levels of Resistin, Adiponectin, and Leptin in Obese Children

비만 아동의 혈청 Resistin, Adiponectin 및 Leptin 농도에 관한 연구

  • Lee Hyun Sook (Department of Sports Science, Seoul Sports Graduate University) ;
  • Choi Jin Sun (Department of Food and Nutrition, Ewha Womans University) ;
  • Kim Wha Young (Department of Food and Nutrition, Ewha Womans University)
  • 이현숙 (서울스포츠대학원대학교 스포츠과학학과) ;
  • 최진선 (이화여자대학교 식품영양학과) ;
  • 김화영 (이화여자대학교 식품영양학과)
  • Published : 2005.04.01


Resistin, adiponectin, and leptin are hormones secreted by adipose tissue and are known to play an important role in adipose tissue metabolism. The purpose of this study was to evaluate the levels of adipocyte-derived hormones (resistin, adiponectin, leptin) in obese children aged 10-12 years. The subjects were 102 obese children with obesity index (OI) over $120\%$ and 51 control children with obesity index less than $120\%$ were included for comparison. Anthropometric variables and serological parameters were assessed. Height, weight, OI, body mass index (BMI) were significantly higher in obese group than in control. Obese children showed significantly higher serum concentrations of triglyceride (TG), total cholesterol (TC), and LDL-cho1esterol and significantly lower HDL-cholesterol compared with control children, even though the values were within normal ranges for both groups. Concentrations of resistin and leptin were significantly higher in obese group than in control. Adiponectin and insulin levels were tended to lower in obese group even though the differences were not statistically significant. Resistin had significant positive correlation with OI and TG, and 1eptin with weight, OI, BMI, TG and TC. On the other hand, adiponectin showed significant negative correlations with height, OI and BMI. These finding showed that obese children had higher serum levels of resistin and leptin and lower adiponectin, and also these hormones had correlations with related factors of obesity, suggesting adipocyte-derived hormones has a role in child obesity.


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