Localized and disseminated histiocytic sarcoma in two dogs

개에서 국소형과 범발성형 조직구육종 2예

  • Kwon, Hyo-Jung (College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Park, Mi-Sun (College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Oh, Sang-Yeon (College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Jee, Hyang (College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Cho, Doo-Youn (Louisiana State University, College of Veterinary Medicine) ;
  • Kim, Dae-Yong (College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
  • 권효정 (서울대학교 수의과대학 병리학교실) ;
  • 박미선 (서울대학교 수의과대학 병리학교실) ;
  • 오상연 (서울대학교 수의과대학 병리학교실) ;
  • 지향 (서울대학교 수의과대학 병리학교실) ;
  • 조두연 (미국 루이지애나주립대 수의과대학) ;
  • 김대용 (서울대학교 수의과대학 병리학교실)
  • Accepted : 2005.08.22
  • Published : 2005.09.22

Abstract

A male mixed breed dog with unknown age (case 1) and 5-year-old female golden retriever (case 2) were admitted to the Department of Veterinary Pathology at College of Veterinary Medicine, Seoul National University after sudden death. At necropsy, stifle region of case 1 was replaced by coalescing firm tan nodules approximately 1-3 cm in diameter. Neoplastic nodules were also presented in the lung. In case 2, the spleen was enlarged 3-5 times its normal size and numerous firm tan nodules were noted in the kidney, pericardium, diaphragm and lymph nodes. Histopathologically, the neoplastic masses of case 1 consisted of plump spindle cells having abundant cytoplasm and indistinct cell borders that formed interlacing bundle. In case 2, the masses were consisted of round to polygonal cells with abundant eosinophilic cytoplasm and eccentric nuclei. Numerous multinucleated giant cells containing nuclei of various sizes were noted. Immunohistochemically, neoplastic cells of all two cases stained intensely with vimentin and lysozyme. Based on the gross and light microscopic findings together with immunohistochemistry, both cases were diagnosed as localized histiocytic sarcoma with pulmonary metastasis and disseminated histiocytic sarcoma, respectively.

Acknowledgement

Supported by : 수의과학연구소

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