Eliminatory Effect of Health Drink Containing Hovenia Dulcis Thunb Extract on Ethanol-Induced Hangover in Rats

헛개나무 열매 추출물을 함유한 건강음료의 숙취 제거 효과

  • Park, Eun-Mi (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark) ;
  • Ye, Eun-Ju (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark) ;
  • Kim, Soo-Jung (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark) ;
  • Choi, Hyun-Im (Dept. of occupational therapy, Sungduk college) ;
  • Bae, Man-Jong (Dept. of Oriental Medicine Biofood Science, Daegu Haany University)
  • 박은미 ((재) 경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원) ;
  • 예은주 ((재) 경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원) ;
  • 김수정 ((재) 경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원) ;
  • 최현임 (성덕대학 작업치료과) ;
  • 배만종 (대구한의대학교 한방바이오식품과학과)
  • Published : 2006.02.28


This study was conducted to investigate the eliminatory effect of health drink containing Hovenia dulcis Thunb extract on ethanol-induced hangover in rats. Male Sprague-Dawley rats weighing $200{\pm}10\;g$ were given health drink (10 mL/kg) or other company product(10 mL/kg) 30 min before or after 40% ethanol (5 g/kg body weight) ingestion. To study the effect of health drink on blood ethanol concentration, blood was taken from caudal artery at 1, 3, 5 hr and the animal were sacrificed 24 hr after ethanol ingestion. From 1 to 5 hr, health drink pre- or postdosing significantly decreased the ethanol levels in the blood. The acetaldehyde concentration showed decrement in health drink group and other company product group. The activities of ethanol, alcohol dehydrogenase and aldehyde dehydrogenase measured at postdosing, were also not altered by the administration of health drink. Alanine aminotransferase and aspartate aminotransferase activities showed unaltered resulted in all experimental groups compared with the normal group. These results suggest that oral intake of health drink containing Hovenia dulcis Thunb is effective on elimination of ethanol-induced hangover.

숙취해소용 음료로 개발된 건강음료를 각각 알코올(5 g/kg B.W, 40%) 투여 30분 전과 후에 경구적으로 섭취시키고(10 mL/kg) 시간(1, 3 및 5)에 따라 미동맥으로 채혈하여 혈액 중 알코올 농도와 아세트알데히드 농도, 간 조직 중 알코올 대사효소 alcohol dehydrogenase (ADH) 및 aldehyde dehydrogenase(ALDH)의 활성과 간기능 지표 효소(ALT, AST)의 활성 변동을 측정 비교하여 다음과 같은 결과를 얻었다. 알코올 투여 30분 전에 건강음료를 공급하였을 때 혈액 중 알코올 농도는 알코올 투여 1시간 후부터 모든 군에서 급격하게 감소하였으며 알코올 투여 5시간째에 알코올 대조군(EC)에 비해 건강음료 투여군(BE)은 48.4%정도 감소하는 경향을 나타내었다. 또한 아세트알데히드 농도는 알코올 대조군(EC)에 비해 건강음료 투여군(BE)은 15.6%, 타사제품 투여군(P)은 20.3% 낮았다. 알코올 투여 30분 후 숙취해소 음료를 공급하고 5시간 경과 후 건강음료 투여군(AE)의 알코올 농도는 알코올 대조군(EC)에 비해 65.2% 낮은 수치를 나타내었다. 아세트알데히드 농도는 알코올 대조군에 비해 건강음료 투여군(AE)은 36.4% 낮은 0.21 mg/dL 타사제품투여군(P)은 24.2% 낮은 0.25 mg/dL를 나타내었다. 간 조직 중 ADH 활성은 정상군과 알코올을 섭취 한 모든 실험군 사이에 별다른 변동을 관찰할 수 없었다. 숙취해소 음료의 1회 섭취와 체중 1 kg당 5 g의 알코올 1회 투여가 알코올 대사 효소의 활성에 영향을 미치지 못함을 시사하고 있다. 혈청 ALT, AST 활성은 정상군과 알코올 투여 실험군간에 유의적인 차이를 보이지 않았으며 또 건강음료의 음용이 정상적인 간 기능에 영향을 미치지 않는 결과를 볼 때 안전성이 인정된다고 생각된다.


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