Effect of Acanthopanacis cortex Water Extract on Antioxidative Activity, Lipid Profile and Epidermal Thickness in DNCB-induced Allergic Contact Dermatitis Animal Model

오가피열수추출물이 DNCB로 유도된 알레르기성 접촉피부염 흰쥐의 지질대사, 항산화능 및 표피회복능에 미치는 영향

  • 김윤희 (대구대학교 공과대학 식품영양학과) ;
  • 박영숙 (대구대학교 공과대학 식품영양학과)
  • Published : 2006.10.01


The effects of Acanthopanacis cortex water extract on allergic contact dermatitis (ACD) in Sprague-Dawley male rats treated with 2.5% 1-chloro-2,4-dinitrochlorobenzene (DNCB) on the dorsal skin were evaluated. The concentration of TBARS in plasma and liver was increased in ACD rats and was significantly decreased in Acanthopanacis cortex fed group (ACFG) compared to CG (control group). Serum Ig E level was significantly increased in CG compared to normal group, while that of ACFG was significantly decreased. The epidermal thickness of CG was significantly increased compared to that of normal group, while that of ACFG was significantly decreased compared to that of CG These results indicated that the Acanthopanacis cortex water extract administration improved lipid preoxidation, antioxidative activity, serum Ig E level and epidermal thickness in rats with ACD.


allergic contact dermatitis;DNCB;Acanthopanacis cortex


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