Effect of Fermented Guava (Psidium guajava L.) Leaf Extract on Hyperglycemia in Low Dose Streptozotocin-induced Diabetic Mice

저용량 Streptozotocin으로 유도된 당뇨모델 생쥐에서 발효 구아바 잎 추출물의 고혈당 억제 효과

  • Published : 2006.10.01

Abstract

The effects of dried and fermented guava (Psidium guajava L.) leaf extracts on blood glucose levels were investigated in low-dose streptozotocin(STZ)-induced diabetic mice. Fermented guava leaf extract (500 mg/kg/day) significantly decreased the fasting blood glucose levels after 2-4 weeks of treatment and improved the impaired glucose tolerance in STZ-induced diabetic mice. On the other hand, dried guava leaf extract lowered the blood glucose levels and improved glucose tolerance two weeks after treatment, but exacerbated STZ-induced high blood glucose levels three and four weeks after treatment. Histological and immunohistochemical observation showed that fermented guava leaf extract treatment improved STZ-induced pancreatic beta-cell damage, but dried guava leaf extract did not affect the damage to the beta-cells. These results suggest that fermented guava (Psidium guajava L.) leaf extracts improve the hyperglycemia by protecting the pancreatic beta-cells hom damage in STZ-induced diabetic mice.

Keywords

guava (Psidium guajava L.);streptozotocin;pancreatic beta-cell;hyperglycemia;glucose tolerance

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