Effect of Fermented Guava (Psidium guajava L.) Leaf Extract on Hyperglycemia in Low Dose Streptozotocin-induced Diabetic Mice

저용량 Streptozotocin으로 유도된 당뇨모델 생쥐에서 발효 구아바 잎 추출물의 고혈당 억제 효과

  • Jin, Yeong-Jun (Department of Life Science and Technology Innovation Center for Life Science, Cheju National University) ;
  • Kang, Shin-Hae (Jeju Hi-Tech Industry Development Institute) ;
  • Choi, Soo-Youn (Department of Life Science and Technology Innovation Center for Life Science, Cheju National University) ;
  • Park, Soo-Young (Jeju Hi-Tech Industry Development Institute) ;
  • Park, Ji-Gweon (Department of Life Science and Technology Innovation Center for Life Science, Cheju National University) ;
  • Moon, Sang-Wook (Fermentech Co. Ltd.) ;
  • Park, Deok-Bae (Department of Medicine, Cheju National University) ;
  • Kim, Se-Jae (Department of Life Science and Technology Innovation Center for Life Science, Cheju National University)
  • 진영준 (제주대학교 생명과학과.생명과학기술혁신센터) ;
  • 강신해 (제주하이테크산업진흥원) ;
  • 최수연 (제주대학교 생명과학과.생명과학기술혁신센터) ;
  • 박수영 (제주하이테크산업진흥원) ;
  • 박지권 (제주대학교 생명과학과.생명과학기술혁신센터) ;
  • 문상욱 ((주)퍼멘텍) ;
  • 박덕배 (제주대학교 의학과) ;
  • 김세재 (제주대학교 생명과학과.생명과학기술혁신센터)
  • Published : 2006.10.01


The effects of dried and fermented guava (Psidium guajava L.) leaf extracts on blood glucose levels were investigated in low-dose streptozotocin(STZ)-induced diabetic mice. Fermented guava leaf extract (500 mg/kg/day) significantly decreased the fasting blood glucose levels after 2-4 weeks of treatment and improved the impaired glucose tolerance in STZ-induced diabetic mice. On the other hand, dried guava leaf extract lowered the blood glucose levels and improved glucose tolerance two weeks after treatment, but exacerbated STZ-induced high blood glucose levels three and four weeks after treatment. Histological and immunohistochemical observation showed that fermented guava leaf extract treatment improved STZ-induced pancreatic beta-cell damage, but dried guava leaf extract did not affect the damage to the beta-cells. These results suggest that fermented guava (Psidium guajava L.) leaf extracts improve the hyperglycemia by protecting the pancreatic beta-cells hom damage in STZ-induced diabetic mice.


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