Effects of Keumsa Sangwhang (Phellinus linteus) Mushroom Extracts on the Natural Killer Cell Activity in Human

금사상황버섯 추출물이 사람의 natural killer 세포 활성에 미치는 영향

  • Eom, Sang-Yong (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Zhang, Yan-Wei (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Kim, Nam-Sik (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Kang, Jong-Won (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Hahn, Youn-Soo (Department of Pediatrics, College of Medicine, Chungbuk National University) ;
  • Shin, Kyeong-Seob (Department of Laboratory Medicine, College of Medicine, Chungbuk National University) ;
  • Song, Hyung-Gen (Department of Pathology, College of Medicine, Chungbuk National University) ;
  • Park, Soon-Young (Department of Preventive Medicine, College of Medicine, Kyung-Hee University) ;
  • Kim, Jeong-Su (Department of Physiology & Biophysics, College of Medicine, University of Alabama at Birmingham) ;
  • Kim, Heon (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Kim, Yong-Dae (Department of Preventive Medicine, College of Medicine, Chungbuk National University)
  • 엄상용 (충북대학교 의과대학 예방의학교실) ;
  • 장연위 (충북대학교 의과대학 예방의학교실) ;
  • 김남식 (충북대학교 의과대학 예방의학교실) ;
  • 강종원 (충북대학교 의과대학 예방의학교실) ;
  • 한윤수 (충북대학교 의과대학 소아과학 교실) ;
  • 신경섭 (충북대학교 의과대학 진단검사의학교실) ;
  • 송형근 (충북대학교 의과대학 병리학교실) ;
  • 박순영 (경희대학교 의과대학 예방의학교실) ;
  • 김정수 (알라바마 의과대학 생리 및 생물물리학과) ;
  • 김헌 (충북대학교 의과대학 예방의학교실) ;
  • 김용대 (충북대학교 의과대학 예방의학교실)
  • Published : 2006.10.01

Abstract

A randomized, double blind, placebo-controlled human intervention study involving 62 healthy volunteers was performed to investigate the effects of Keumsa sangwhang (Phellinus linteus) mushroom extracts (KPLE) on natural killer (NK) cell activity in peripheral blood. The volunteers were randomly distributed into two groups, one receiving KPLE (3.3 g/day) and the other a placebo by oral administration for 8 weeks. In this study, the number of NK cells did not increase with KPLE administration, however the cytotoxic activity of NK cells against the Jurkat leukemia cell line increased significantly. This result suggests that administration of KPLE induces cell-mediated immunity by increasing NK cell activity in humans.

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