한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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헛개나무 열매를 주성분으로 제조한 새로운 처방이 알코올 분해 및 간 손상에 미치는 영향

Effect of New Remedies Mainly Comprised of Hovenia dulcis Thunb on Alcohol Degradation and Liver Protection in Sprague Dawley Male Rats

  • 발행 : 2006.08.30

초록

본 연구에서는 헛개나무열매를 주성분으로 제조한 두 종류의 혼합물들(NHDT-1과 NHDT-2)이 알코올 및 아세트알데히드의 분해를 촉진시켜 숙취의 발생을 저하시킬 수 있는지 여부와 만성적으로 알코올을 복용시켰을 때 간손상 및 지방간의 발생을 억제할 수 있는지 여부를 조사하였다. NHDT-1은 헛개나무열매에 진피, 창출 및 감초를 첨가하여 제조하였고, NHDT-2는 NHDT-1에 홍삼을 첨가하여 제조하였다. NHDT-1과 NHDT-2의 조성 차이는 홍삼임에도 불구하고 백서에게 투여하였을 때 알코올 및 아세트알데히드의 분해와 간손상을 억제하는 작용에는 차이가 있었다. 홍삼이 함유되어있지 않은 NHDT-1은 급성 알코올 실험에서 알코올 및 아세트알데히드 분해를 촉진시켜 혈청농도를 저하시켰으나, 홍삼이 함유된 NHDT-2는 혈청 알코올과 아세트알데히드 농도를 저하시키지 못했다. 급성실험과는 반대로 장기간 알코올을 투여한 실험에서는 NHDT-1은 NHDT-2에 비해 알코올로 인한 간의 손상과 지방간 발생을 억제하지 못했다. 결론적으로 간기능이 좋은 상태에서 일시적으로 복용하는 경우에는 NHDT-1이 알코올과 아세트알데히드의 분해를 촉진하여 숙취해소에 효과적이지만, 간이 좋지 않은 상태에서는 장기간동안 NHDT-2를 복용하여 간의 기능을 향상시키는 것이 음주 후 숙취제거에 효과적일 것으로 사료된다.

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참고문헌

  1. The division of National Nutrition Survey. 2002. 2001 National Nutrition Survey Report in Korea. Ministry of Health and Welfare, Seoul
  2. Wrase J, Grusser SM, Klein S, Diener C, Hermann D, Flor H, Mann K, Braus DF, Heinz A. 2002. Development of alcohol-associated cues and cue-induced brain activation in alcoholics. Eur Psychiatry 17: 287-291
  3. Lieber CS, Leo MA. 1992. Alcohol and liver. In Medical and nutritional complications of alcoholism: mechanism and management. Lieber CS, ed. Plenum Medical Book Co., New York. p 185
  4. Lieber CS, Garro A, Leo MA, Mak KM, Worner T. 1986. Alcohol and cancer. Hepatology 6: 1005-1019 https://doi.org/10.1002/hep.1840060533
  5. Hawkins RD, Kalant H. 1972. The metabolism of ethanol and its metabolic effects. Pharmacol Rev 24: 67-157
  6. Forsander OA, Raiha Niels CR. 1960. Metabolites produced in the liver during alcohol oxidation. J Biol Chem 235: 34-36
  7. Kim TJ. 1996. Korean resources plants. Seoul National University Press, Seoul. p 72
  8. Park KJ, Lee MJ, Kang HM, Kim KS, Lee SH, Cho IH, Lee HH. 2002. Saeng-Maek-San, a medicinal herb complex, protects liver cell damage induced by alcohol. Biol Pharm Bull 25: 1451-1455 https://doi.org/10.1248/bpb.25.1451
  9. Lin CF, Wong KL, Wu RS, Huang TC, Liu CF. 2003. Protection by hot water extract of Panax notoginseng on chronic ethanol-induced hepatotoxicity. Phytother Res 17: 1119-1122 https://doi.org/10.1002/ptr.1329
  10. Siegmund SV, Brenner DA. 2005. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res 29: 102S-109S https://doi.org/10.1097/01.alc.0000189275.97419.58
  11. Takeuchi M, Saito T. 2005. Cytotoxicity of acetaldehyde- derived advanced glycation end-products (AA-AGE) in alcoholic-induced neuronal degeneration. Alcohol Clin Exp Res 29: 220S-224S https://doi.org/10.1097/01.alc.0000190657.97988.c7
  12. Cho JY, Moon JH, Park KH. 2000. Isolation and identification of 3-methoxy-4-hydroxybenzoic acid and 3-methoxy-4-hydroxycinnamic acid from hot water extracts of Hovenia dulcis Thunb and confirmation of their antioxidative and antimicrobial activity. Korean J Food Sci Technol 32: 1403-1408
  13. Yang DS, Hong SG, Choi SM, Kim BN, Sung HJ, Yoon YS. 2004. Effect of an oriental herbal composition, Jang Baek union (JBU), on alcohol-induced hangover and CCL4- induced liver injury in rats. J Korean Soc Food Sci Nutr 33: 78-82 https://doi.org/10.3746/jkfn.2004.33.1.078

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  10. Mulberry and dandelion water extracts prevent alcohol-induced steatosis with alleviating gut microbiome dysbiosis vol.243, pp.11, 2018, https://doi.org/10.1177/1535370218789068
  11. Hangover Relieving through Algae and Plant Complex Extract using Lava Sea Water vol.22, pp.2, 2018, https://doi.org/10.13050/foodengprog.2018.22.2.110