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Anticancer (in vitro) and Antiallergy Effects of Rice Bran Extracts

쌀겨 추출물의 항암효과(in vitro) 및 항알레르기 효과

  • Choi, Hyun-Im (Dept. of Occupational therapy, Sungduk college) ;
  • Ye, Eun-Ju (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark) ;
  • Kim, Soo-Jung (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark) ;
  • Bae, Man-Jong (Dept. of Herbal foodceutical Science, Daegu Haany University) ;
  • Yee, Sung-Tae (Dept. of Biology, Sunchon National University) ;
  • Park, Eun-Jung (Dept. of Biology, Sunchon National University) ;
  • Park, Eun-Mi (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Hanny University, Kyongbuk Technopark)
  • 최현임 (성덕대학 작업치료과) ;
  • 예은주 ((재)경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원) ;
  • 김수정 ((재)경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원) ;
  • 배만종 (대구한의대학교 한방식품약리학과) ;
  • 이성태 (순천대학교 생물학과) ;
  • 박정은 (순천대학교 생물학과) ;
  • 박은미 ((재)경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원)
  • Published : 2006.12.29

Abstract

This study was conducted to investigate the anticancer (in vitro) and antiallergy effects of rice bran extracts. In an anticancer test using Hep3B cells and HeLa cells, water and 60% ethanol extracts of rice bran inhibited the growth of Hep3B and HeLa cell lines and morphological changes were also observed. In Hep3B cell lines, water extract of rice bran showed a higer antiproliferating effect than 60% ethanol extract. The growth-inhibitory effect against HeLa cells were 30.9% for $1,000{\mu}g/mL$, 88.8% for $3,000{\mu}g/mL$ rice bran water extract. The expressions of $Fc{\varepsilon}RI$ mRNA and c-kit in HMC-1 (human mast cell) were decreased by 60% ethanol treatment but tryptase mRNA was not changed. The extracts of rice bran inhibited histamine release from RPMC (rat peritoneal mast cell) activated by compound 48/80. Rice bran water extract showed inhibitory effect of 87% at $0.01{\mu}g/mL$ concentration and 60% ethanol extract inhibited the release of histamine by 86% at $100{\mu}g/mL$ concentration.

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