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Antioxidant and Anticancer Activities of Water Extracts from Ceramium kondoi

비단풀 물 추출물의 항산화력 및 항암활성

  • An, Deok-Ho (Gaya Elementary School) ;
  • Cho, Seug-Ja (Munam Elementary School) ;
  • Jung, Eun-Sil (Dept. of Food Science and Biotechnology, Kyungnam University) ;
  • Lee, Hyun-Jin (Dept. of Food and Nutritional Sciences, Kyungnam University) ;
  • Hwang, Ji-Hwan (Dept. of Food Science and Biotechnology, Kyungnam University) ;
  • Park, Eun-Ju (Dept. of Food and Nutritional Sciences, Kyungnam University) ;
  • Park, Hae-Ryong (Dept. of Food Science and Biotechnology, Kyungnam University) ;
  • Lee, Seung-Cheol (Dept. of Food Science and Biotechnology, Kyungnam University)
  • 안덕호 (함안 가야초등학교) ;
  • 조석자 (함안 문암초등학교) ;
  • 정은실 (경남대학교 식품생명학과) ;
  • 이현진 (경남대학교 식품영양학과) ;
  • 황지환 (경남대학교 식품생명학과) ;
  • 박은주 (경남대학교 식품영양학과) ;
  • 박해룡 (경남대학교 식품생명학과) ;
  • 이승철 (경남대학교 식품생명학과)
  • Published : 2006.12.29

Abstract

The present study describes the preliminary evaluation of the antioxidant activity and the cytotoxic effect of Ceramium kondoi. The antioxidant activities and cytotoxic effect of the water extracts were evaluated by total phenolic contents (TPC), DPPH radical scavenging activity (RSA), reducing power (RP), comet assay, and MTT reduction assay. TPC, DPPH RSA, and RP of the extract at the concentration of $1,000{\mu}g/mL$ was $659.2{\mu}M$, 86.0%, and 1.084, respectively, and those were concentration dependent. The $200{\mu}M\;H_2O_2-induced$DNA damage was inhibited by C. kondoi water extract in a dose dependent manner in human leukocytes. The inhibition was by 62.3, 39.8, 24.8% and 16.4% at the concentration of 5, 10, $25{\mu}g/mL$ and $50{\mu}g/mL$, respectively. Cytotoxic activity on HT-29 cells and MCF-7 cells of the C. kondoi water extract at the concentration of $10{\mu}g/mL$ was 49% and 60%, respectively. These results strongly support the possibility of C. kondoi as a source of natural functional materials.

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