Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Antioxidant and Anticancer Activities of Water Extracts from Ceramium kondoi

비단풀 물 추출물의 항산화력 및 항암활성

  • An, Deok-Ho (Gaya Elementary School) ;
  • Cho, Seug-Ja (Munam Elementary School) ;
  • Jung, Eun-Sil (Dept. of Food Science and Biotechnology, Kyungnam University) ;
  • Lee, Hyun-Jin (Dept. of Food and Nutritional Sciences, Kyungnam University) ;
  • Hwang, Ji-Hwan (Dept. of Food Science and Biotechnology, Kyungnam University) ;
  • Park, Eun-Ju (Dept. of Food and Nutritional Sciences, Kyungnam University) ;
  • Park, Hae-Ryong (Dept. of Food Science and Biotechnology, Kyungnam University) ;
  • Lee, Seung-Cheol (Dept. of Food Science and Biotechnology, Kyungnam University)
  • 안덕호 (함안 가야초등학교) ;
  • 조석자 (함안 문암초등학교) ;
  • 정은실 (경남대학교 식품생명학과) ;
  • 이현진 (경남대학교 식품영양학과) ;
  • 황지환 (경남대학교 식품생명학과) ;
  • 박은주 (경남대학교 식품영양학과) ;
  • 박해룡 (경남대학교 식품생명학과) ;
  • 이승철 (경남대학교 식품생명학과)
  • Published : 2006.12.29

Abstract

The present study describes the preliminary evaluation of the antioxidant activity and the cytotoxic effect of Ceramium kondoi. The antioxidant activities and cytotoxic effect of the water extracts were evaluated by total phenolic contents (TPC), DPPH radical scavenging activity (RSA), reducing power (RP), comet assay, and MTT reduction assay. TPC, DPPH RSA, and RP of the extract at the concentration of $1,000{\mu}g/mL$ was $659.2{\mu}M$, 86.0%, and 1.084, respectively, and those were concentration dependent. The $200{\mu}M\;H_2O_2-induced$DNA damage was inhibited by C. kondoi water extract in a dose dependent manner in human leukocytes. The inhibition was by 62.3, 39.8, 24.8% and 16.4% at the concentration of 5, 10, $25{\mu}g/mL$ and $50{\mu}g/mL$, respectively. Cytotoxic activity on HT-29 cells and MCF-7 cells of the C. kondoi water extract at the concentration of $10{\mu}g/mL$ was 49% and 60%, respectively. These results strongly support the possibility of C. kondoi as a source of natural functional materials.

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References

  1. Choi JG. 2006. The medicine of grasses, flowers and trees 2. Hanmunwha, Seoul, Korea. p 193-201
  2. Gutteridge JMC, Halliwell B. 1994. Antioxidants in nutrition, health, and disease. Oxford University Press, Oxford, UK. p 1-62
  3. Jayat C, Ratinaud MH. 1993. Cell cycle analysis by flow cytometry: principles and application. Biol Cell 78: 15-25 https://doi.org/10.1016/0248-4900(93)90110-Z
  4. Chance B, Sies H, Boveris A. 1979. Hydroperoxide metabolism in mammalian organs. Physiol Rev 59: 527-605 https://doi.org/10.1152/physrev.1979.59.3.527
  5. National Statistical Office. 2004. Annual Report on the Cause of Death Statistics. Seoul, Korea
  6. Kim HJ, Wang SK. 1997. Dietary factors related with cancer. Liv Sic of Tj Univ 3: 99-130
  7. Lee SR. 1993. Food Safety Research. Ewha Woman's University Press, Seoul
  8. Kang TB, Liang NC. 1997. Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochem Pharm 54: 1013-1018 https://doi.org/10.1016/S0006-2952(97)00260-8
  9. Park KY, Moon SH, Rhee SH, Baek KY, Lim SY. 1995. Effect of tannin from persimmon leaves on the growth inhibition and the synthesis of mRNA of type IV collagen in AZ-521 human gastric cancer cells. Envirron Mut Carcino 15: 32-37
  10. Grever MCB. 2001. Cancer drug discovery and development. In Cancer: Principles and Practice of Oncology. De Vita VHS, Rosenberg SA, eds. Lippincott-Raven, Philadelphia, USA. p 328-339
  11. Gutfinger T. 1981. Polyphenols in olive oil. J Am Oil Chem Soc 58: 966-968 https://doi.org/10.1007/BF02659771
  12. Jeong SM, Kim SY, Park HR, Lee SC. 2004. Effect of far-infrared radiation on the activity of extracts from Citrus unshiu peels. J Korean Soc Food Sci Nutr 33: 1580-1583 https://doi.org/10.3746/jkfn.2004.33.9.1580
  13. Oyaizu M. 1986. Studies on product of browning reaction prepared from glucose amine. Jpn J Nutr 44: 307-315 https://doi.org/10.5264/eiyogakuzashi.44.307
  14. Shahidi F, Wanasundara PK. 1992. Phenolic antioxidant. Crit Rev Food Sci Nutr 32: 67-103 https://doi.org/10.1080/10408399209527581
  15. Herrmann K. 1989 Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods. Crit Rev Food Sci Nutr 28: 315-347 https://doi.org/10.1080/10408398909527504
  16. Meir S, Kanner J, Akiri B, Philosoph-Hadas S. 1995. Determination and involvement of aqueous reducing compounds in oxidative defense systems of various senescing leaves. J Agric Food Chem 43: 1813-1819 https://doi.org/10.1021/jf00055a012

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