Effects of Silk Protein Hydrolysates on Blood Glucose and Serum Lipid in db/db Diabetic Mice

실크단백질 효소 가수분해물이 2형 당뇨 마우스의 혈당 및 혈청지질에 미치는 영향

  • Shin, Mi-Jin (Dept. of Food Science and Nutrition, Dankook University) ;
  • Park, Min-Jeong (Dept. of Food Science and Nutrition, Dankook University) ;
  • Youn, Myung-Sub (Dept. of Food Science and Nutrition, Dankook University) ;
  • Lee, Young-Sook (Dept. of Food Science and Nutrition, Dankook University) ;
  • Nam, Moon-Suk (Dept. of Internal Medicine, Inha University, College of Medicine) ;
  • Park, In-Sun (Dept. of Anatomy, Inha University, College of Medicine) ;
  • Jeong, Yoon-Hwa (Dept. of Food Science and Nutrition, Dankook University)
  • 신미진 (단국대학교 식품영양학과) ;
  • 박민정 (단국대학교 식품영양학과) ;
  • 윤명섭 (단국대학교 식품영양학과) ;
  • 이영숙 (단국대학교 식품영양학과) ;
  • 남문석 (인하대학교 의과대학 내과학교실) ;
  • 박인선 (인하대학교 의과대학 해부학교실) ;
  • 정윤화 (단국대학교 식품영양학과)
  • Published : 2006.12.29


This study was performed to investigate the effects of silk protein enzyme hydrolysates on blood glucose and serum lipid in db/db diabetic mice. Twelve week-old-male C57BL/KsJ db/db mice were divided into two groups: diabetic control group and 0.25% silk protein hydrolysates solution group, which were fed for 8 weeks. Body weight increased in the silk protein hydrolysates group compared with the diabetic control group. There were no differences in food and water intake between the diabetic control and the silk protein hydrolysates groups. The weight of liver increased in the silk protein hydrolysates group while that of kidney increased in the diabetic control group. The blood glucose level increased about 18.0% in the diabetic control group after 8 weeks while that in the silk protein hydrolysates group increased about 5.8%. Also, silk protein hydrolysates improved the glucose tolerance in C57BL/KsJ db/db mice. There was no difference in total cholesterol and non-HDL cholesterol concentration between the diabetic control and the silk protein hydrolysates group. Triglyceride concentration were lower in the silk protein hydrolysates group than in the diabetic control group (p<0.05) while HDL-cholesterol concentration were higher in the silk protein hydrolysates group than in the diabetic control group (p<0.05). This results suggest that administration of silk protein enzyme hydrolysates reduces significantly an increasing rate of 1]food glucose, decreases triglyceride, and increases HDL-cholesterol in C57BL/KsJ db/db mice.


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