Comparison of Haseman-Elston Linkage Tests with Age-of-Onset or Affection Trait

  • Jung, Kyoung-Hee (Department of Biostatistics, The Catholic University of Korea) ;
  • Song, Hae-Hiang (Department of Biostatistics, The Catholic University of Korea)
  • Published : 2006.12.31


In this paper, we perform a simulation study of genetic model-free age-of-onset methods in linkage tests which has been proposed by Zhu et al. (1997). They performe. Haseman-Elston regression on a set of bipolar pedigree data using each of three dependent variables: a binary trait indicating disease concordance or discordance, a binary trait adjusted for age-of-onset, and the residuals from a survival analysis. We compare the powers of the proposed test statistics for various situations. Simulations that we have carried out show that the gains in power are observed when the residuals from a survival analysis are used in linkage tests.


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