DOI QR코드

DOI QR Code

An Electrical Signal Detection System Using Nanoparticle for a Microbiochip

나노입자를 이용한 마이크로 바이오칩의 전기적 신호검출

  • Published : 2006.01.01

Abstract

A system for the electrical bio signal detection for a microchip is proposed. Gold nanoparticles were selected for the system for their bio-compatibility and potential for higher sensitivity with large surface areas. For the estimation of the conductivity of gold nanoparticles, microchips with interdigitated microelectrodes of 3,5,7 and $9\;{\mu}m$ spacing were fabricated. In addition, a simulation program was developed to estimate the electrical resistance of the fabricated microchip. The results of conduction simulation for the nanoparticles show good agreements with experimental data, which validate the proposed system.

Keywords

Microbiochip;Electrical Detection;Nanoparticle;Conductivity;Microelectrode;MEMS

References

  1. Nicolini, C., 1995, 'From Neural Chip and Engineering Biomolecules to Bioelectronic Devices : and Overview,' Biosensors & Bioelectronics, Vol. 1, No. 1/2, pp. 105-127 https://doi.org/10.1016/0956-5663(95)96799-5
  2. Park.J.G, 2000, 'Biochip Technology and Application,' Proceeding of KIEE, Vol. 49, No. 2, pp. 17-23
  3. Albers, J., Grunwald, T., Nebling, E., Piechotta, G., Hintsche, R., 2003, 'Electrical Biochip Technology - a Tool for Microarrays and Continuos Monitoring,' Analytical and Bioanalyical Chemistry, Vol. 377, No. 3, pp. 521-527 https://doi.org/10.1007/s00216-003-2192-7
  4. Vo-Dinh, T., Cullum, B., 2000, 'Biosensors and Biochips : Advance in Biological and Medical Diagnostics,' Fresenius Journal of Analytical Chemistry, Vol. 366, pp. 540-551 https://doi.org/10.1007/s002160051549
  5. Harris, T., 2000, 'Genetics, Genomics and Drug Discovery,' Medicinal Research Reviews, Vol. 20, pp. 203-211 https://doi.org/10.1002/(SICI)1098-1128(200005)20:3<203::AID-MED4>3.0.CO;2-G
  6. Kerman, K., Kobayashi. M., Tamiya, E., 2004, 'Recent Trends in Electrochemical DNA Biosensor Technology,' Measurement science & technology,' Vol.15, pp. R1-R11 https://doi.org/10.1088/0957-0233/15/2/R01
  7. Yoshio O., Yuka M., Kuniharu I., Masayuki M., Akia M., and Keisuke M., 1992, 'Hybridization of Nuclec Acids Immobilized on a Quartz Crystal Microbalance,' Journal of the American Chemical Society, Vol. 114, pp. 8299-8300 https://doi.org/10.1021/ja00047a056
  8. Schwarz, M. A., Hauser, P. C., 2001, 'Recent Development in Detection Methods for Microfabricated Analytical Devices,' Lab on a chip, Vol. 1,pp. 1-6 https://doi.org/10.1039/b103795c
  9. Wang, J., 2003, 'Nanoparticle-Based Electrochemical DNA Detection,' Analytica Chimica Acta, Vol. 500. pp. 247-257 https://doi.org/10.1016/S0003-2670(03)00725-6
  10. Piunno, P., Krull, U., Hudson, R., Dahma, M., Cohen, H., 1995, 'Fiber-Optic DNA Sensor for Fluorometric Nucleic Acid Determination' Analytical Chemistry, Vol. 67, pp. 2635-2643 https://doi.org/10.1021/ac00111a022
  11. Park.S.J, Taton, T.A., Mirkin, C. A., 2002, 'Array-Based Electrical Detection with Nanoparticle probes,' SIENCE, Vol. 295, No. 5559, pp. 1506-1508 https://doi.org/10.1126/science.1067003
  12. Burnmeister, J., Bazilyanska, V., Grothe, K., Koehelr, B., Dorn, I., Warner, B.D., Diesel, E., 2004, 'Single Nucleotide Polymorphism Analysis by Chip-Based Hybridization and Direct Current Electrical Detection of Gold-Labeled DNA,' Analytical Bioanalyticl Chemisty, Vol. 379, No. 3, pp. 391-398 https://doi.org/10.1007/s00216-004-2601-6
  13. Haguet, V., Martin, D., .Marcon, L., Heim, T., Stievenard, D., Oliver, C., El-Mahdi, O., Melnyk, O., 2004, 'Combined Nanogap Nanoparticles Nanosensor for Electrical Detection of Biomolecular Interactions Between Polypeptides' Applied Physics Letters, Vol. 84, No. 7, pp. 12113-1215 https://doi.org/10.1063/1.1648135
  14. Moller, R., Csaki, A., Kohler, J. M., Fritzsche, W., 2001, 'Electrical Classification of the Concentration of Bioconjugated Metal Colloids After Surface Adsorption and Silver Enhancement,' Langmuir, Vol. 14, pp. 5426-5430 https://doi.org/10.1021/la0102408
  15. Hyatt, M.A., 1989, 'Colloidal Gold : Principles, Methods and Applications,' Academic Press, pp. 1-32
  16. Park, J.J., 2005, 'A Study on an Electrical Biosignal Detection System for the Microbiochip' KSPE, Vol. 22. No. 4