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A Study on the Pharmacetical Characteristics & Analysis of Glycyrrhizin Extract

감초 추출물의 약리적 특성 및 분석

  • Sung, Ki-Chun (Department of Chemical Engineering, Dae Jin University)
  • 성기천 (대진대학교 공과대학 화학공학과)
  • Published : 2006.09.30

Abstract

From experiment results on pharmacetical characteristics and analysis of Glycyrrhizin extract, some conclusions are obtained as follows. From results on extract experiment of Glycyrrhizin, it appeared about 8%-extraction ratio as semi-solid state, and after dried in freezing from Glycyrrhizin extract of semi-solid state, it obtained about 70%-Glycyrrhizin extract as solid state of yellow gold color. From results on antimicrobial experiment of Glycyrrhizin extract, number of S-typhimurium and Fungus in microbe decreased more and more according to time passage. This phenomenon shows that Glycyrrhizin extract keeps antimicrobial effect. From results on antioxidation experiment of Glycyrrhizin extract, DPPH scavenging activity of free radical shows that Glycyrrhizin extract appears more remarkable reduction ability than reference samples. This phenomenon means that antioxidation of Glycyrrhizin extract appears higher than Vitamin-C and BHA. From results on instrument analysis, the fatty and aromatic components of 2-pentanone, cyclohexasiloxane, tetrasiloxane, benzoquinoline-2-carboxylic acid etcs from Glycyrrhizin extract was detected with GC/MS and inorganic components of Ca, Mg, Ti, Zn, Fe etcs from Glycyrrhizin extract was detected with ICP/OES.

References

  1. T. Akao, M. Hattori M. Kanaok, K. Yamamoto, T. Namba, and K. Kobahashi, Biochemical Pharmacology, 41, 1025 (1991) https://doi.org/10.1016/0006-2952(91)90210-V
  2. H. S. Koo, Theoretical Review on Biopharmacological Efficacy of Glycyrrhizae Radix, College of Oriental Medicine, Graduate School, Dong Eui University, p.p 1-2 (2005)
  3. G. S. Lee, Practice of Microbiology, Bureau of Publication, 329 (1992)
  4. J. Kim, Inhibitory Effect and Mechanism on Melanogenesis of Glycyrrhizae Water Extract, Graduate School, Won Kwang University, p.p 1-16 (2002)
  5. D. W. Lim, Influence on the Glycyrrhizin Extract Affects Increase of Melanin Cell and Melanin, Paper of Dong Seo Medicine Reserch Institute, p.p 247-254 (2001)
  6. H. Y. HSU, Oriental Materia Medica, The Oriental Healing Arts Industry, p.p 532-533 (1986)
  7. S. Provel and F. A. Muskiet, Melanin Metabolites as Markers for Pigmented Malignant Melanoma, Cancer Detection and Prevention, 6, 311 (1993)
  8. G. Prota, Recent Advances in the Chemistry of Melanogenesis in Mammals, J. Invest Dermatol, 75, 122 (1980) https://doi.org/10.1111/1523-1747.ep12521344
  9. K. C. Huang, The Pharmacology of Chinese Herbs, CRO Press, p.p 275-277 (1993)
  10. S. J. Kim, Optimization of Extraction Conditions for the Antimicrobial and Antioxidative Materials from Glycyrrhiza Glabra and Investigation of its Activity, Graduate School, An Dong University, p.p 1-3 (2003)
  11. W. T. Cung, A Study on the Research and Application of Physiological Activation in Domestic Glycyrrhizin, Graduate School, Gang Won University, p.p 3-10 (2002)
  12. Y. C. Park, S. D. Lee, Y. S. Lee, Efficacy and Poisonous Character of Glycyrrhizin, Korean J. Pois. Char., 18, p.p 301-309 (2002)
  13. Y. Y. Ahn, D. H. Shin, N. Y. Paek, J. Y. Oh, Separation and Structure of Antimicrobial Activity Materials from Glycyrrhizin, Korean J. Food Sci., 30, p.p 680-678 (1998)
  14. M. S. Blois, Nature, 181, p.p 1199-1200 (1958) https://doi.org/10.1038/1811199a0
  15. H. K. Kim, Pharmacetics of Chinse Medicine, Seoul, Yung Lim Co., p.p 315-318 (2000)
  16. Committee of Herb Medicine School, Herb Medicine Pharmacognosy, Revision 3rd Edition, p.p 90-97 (1998)