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Association of MC4R Gene Polymorphisms with Growth and Body Composition Traits in Chicken

  • Li, Chun-Yu (College of Animal Science and Technology, Northeast Agricultural University) ;
  • Li, Hui (College of Animal Science and Technology, Northeast Agricultural University)
  • Received : 2005.08.18
  • Accepted : 2006.01.09
  • Published : 2006.06.01

Abstract

Genetic and pharmacological studies in mice have demonstrated a complementary role for the melanocortin 4 receptor (MC4R) in the control of food intake, energy balance and body weight. This study was designed to investigate the associations of a MC4R gene polymorphism on chicken growth and body composition traits in broiler lines divergently selected for abdominal fat. A SNP (G54C) was found in CDS region of chicken MC4R gene. The analysis of the least squares and variance revealed a significant association between the G54C SNP and BW, CW and SL at 7 wk of age, and there were significant differences in different genotypes (p<0.05). The results from protein secondary structure prediction and tertiary structure prediction showed that it appeared a helix in $13^{th}$ amino acid and two strands at $14^{th}$ and $15^{th}$ amino acid in mutant protein, respectively. It maybe induce the change of the activity or function of MC4R gene in poultry.

Keywords

Melanocortin 4 Receptor;SNP;Body Weight;Body Composition;Chicken

Acknowledgement

Supported by : National Natural Science Foundation

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