Effects of Cyclooxygenase-2 Expression on Lymphangiogenesis and Lymph Node Metastasis in Gastric Cancer Tissues

위암조직에 있어 COX-2 발현이 림프관신생과 림프절 전이에 미치는 영향

  • Chun, Hu-An (Departments of Surgery, College of Medicine, Hanyang University) ;
  • Paik, Seung-Sam (Departments of Pathology, College of Medicine, Hanyang University) ;
  • Song, Young-Soo (Departments of Pathology, College of Medicine, Hanyang University) ;
  • Kwon, Sung-Joon (Departments of Surgery, College of Medicine, Hanyang University)
  • 전후완 (한양대학교 의과대학 외과학교실) ;
  • 백승삼 (한양대학교 의과대학 병리학교실) ;
  • 송영수 (한양대학교 의과대학 병리학교실) ;
  • 권성준 (한양대학교 의과대학 외과학교실)
  • Published : 2006.12.30


Purpose: Many previous studies have suggested that cyclooxygenase-2 (COX-2) over expression is closely related to angiogenesis. However, few have reported the relationship between COX-2 and lymphangiogenesis which is still unclear, The aim of this study was to determine the relationship between COX-2 expression and lymphangiogenetic factor, VEGF-C, in human gastric cancer and to correlate COX-2 and VEGF-C expression with other clinocopathological features to investigate whether COX-2 contributes to lymphangiogenesis and enhances lymph node metastasis. Materials and Methods: One hundred patients who underwent curative radical surgery in Hanyang University hospital from July 1998 to June 2001 were selected. The expression of COX-2 and VEGF-C were detected by using immunohistochemistry, and the relationships between these two parameters and several clinicopathological factors (gender, stage, lymph node status, tumor location, Lauren classification and angioinvasion) were determined. Results: Increased COX-2 expression was found in 86 of 100 tumor samples (86%) and in 70 of 100 tumor samples (70%) with VEGF-C. A high correlation between VEGF-C expression and lymph node metastasis was observed (P=0.033) along as well as COX-2 expression (P=0.012). Also, there was a significant correlation between COX-2 and VEGF-C expression (P=0.026), yet no correlation were found between COX-2 and VEGF-C expression and other clinicopathological parameters. Conclusion: Our study suggests that COX-2 expression contributes to lymphangiogenesis by mediating VEGF-C and finally promoting lymph node metastasis.