Synthesis of 2(5H)-Furanones and 2-Cycloalkenones and Their Fungicidal Activities

2(5H)-Furanone 및 2-Cycloalkenone 유도체의 합성과 살균활성

  • 허정녕 (한국화학연구원 신약연구단) ;
  • 송영섭 (한국화학연구원 신약연구단) ;
  • 박노균 (한국화학연구원 신약연구단) ;
  • 최경자 (한국화학연구원 신화학연구단) ;
  • 장경수 (한국화학연구원 신화학연구단) ;
  • 김범태 (한국화학연구원 신약연구단)
  • Published : 2007.03.30


We have developed an efficient synthesis of 2(5H)-furanones using the microwave-promoted Suzuki-Miyaura coupling reaction and evaluated their fungicidal activities against six fungal pathogens in vivo. In addition, 2-cyclopentenones or 2-cyclohexenones possessing one or two additional methylene groups instead of the oxygen in the 2(5H)-furanone skeleton were also prepared by using the similar method. As the results of in vivo fungicidal screening against 6 plant diseases, a few derivatives displayed specific fungicidal activities against rice blast and tomato late blast. Further studies toward the optimization of the chemical structures are necessary for the development of novel fungicides with high potency.


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