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Effect of Mycelia Extracts from Lentinus edodes Mushroom-Cultured Astragalus membranaceus Bunge on Anti-cancer and Anti-allergy Activities

황기에 표고버섯 균사체를 배양한 추출물이 항암효과 및 알레르기 억제효과에 미치는 영향

  • Bae, Man-Jong (Dept. of Herbal Foodceutical Science, Daegu Haany University) ;
  • Kim, Kwang-Joong (Dept. of Oriental Medicine, Daegu Haany University) ;
  • Kim, Soo-Jung (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Haany University, Kyungbuk Technopark) ;
  • Ye, Eun-Ju (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Haany University, Kyungbuk Technopark)
  • 배만종 (대구한의대학교 한방식품약리학과) ;
  • 김광중 (대구한의대학교 한의학과) ;
  • 김수정 ((재)경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원) ;
  • 예은주 ((재)경북테크노파크 대구한의대학교 한방생명자원특화센터 효능검증원)
  • Published : 2007.01.31

Abstract

This study was conducted to investigate the effect of mycelia of Lentinus edoes mushroom-cultured Astragalus membranaceus Bunge (LAM) on proliferation of cancer cell lines (Hep3B, MCF-7 and HeLa), sarcoma 180 (S-180), and anti-allergy. In an anti-cancer test using Hep3B (hepatic cancer cell), MCF-7 (breast cancer cell) and HeLa (uterine cancer cell), LAM extract showed higher antiproliferating effect than that of Astragalus membranaceus Bunge (AM) extract. In an anti-cancer testing using Hep3B cells and MCF-7 cells, LAM extract showed growth-inhibitory effect of 65.23% at 3 mg/mL and 69.23% at 5 mg/mL, respectively. In an anti-cancer testing using HeLa cells, LAM extract showed growth-inhibitory effect of 42.01% at 5 mg/mL. In addition, LAM showed the tumor suppressive effect in mice injected with S-180 cells. The growth-inhibitory rates against tumor cells were 47% for LAM and 37% for AM. LAM inhibited histamine release from rat peritoneal mast cells activated by compound 48/80. These results suggest that Lentinus edodes mushroom-cultured herb has an antiproliferating effect against cancer cell lines (Hep3B, MCF-7 and HeLa), S-180 tumor and will be beneficial in the treatment of allergic reaction.

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