Effects of Mulberry Leaf Extract Feeding on Lipid Status of Rats Fed High Cholesterol Diets

뽕잎추출물이 고콜레스테롤 식이 흰쥐의 지질대사에 미치는 영향

  • Park, Surk-Hoon (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Jang, Mi-Jin (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Hong, Jung-Hee (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Rhee, Soon-Jae (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Choi, Kyung-Ho (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Park, Mo-Ra (Dept. of Food Science and Nutrition, Sanju National University)
  • 박석훈 (대구가톨릭대학교 식품영양학과) ;
  • 장미진 (대구가톨릭대학교 식품영양학과) ;
  • 홍정희 (대구가톨릭대학교 식품영양학과) ;
  • 이순재 (대구가톨릭대학교 식품영양학과) ;
  • 최경호 (대구가톨릭대학교 식품영양학과) ;
  • 박모라 (국립상주대학교 식품영양학과)
  • Published : 2007.01.31


This study was to investigate the effect of mulberry leaf water extract on lipid metabolism of rats fed high cholesterol diets. Sprague-Dawley male rats were randomly assigned to two normal groups; mulberry extract-free (N), 0.16% mulberry leaf extract (NM) groups and high cholesterol groups with four different levels of mulberry leaf extract; 0% (HC), 0.08% (HCL), 0.16% (HCM), and 0.32% mulberry leaf extract (HCH) groups. Serum levels of triglyceride, cholesterol, LDL-cholesterol and AI index in mulberry leaf extract supplemented groups were significantly lower than the HC group (p<0.05). The level of HDL-cholesterol in the HC group was significantly (p<0.05) reduced, compared with N group, but it was increased by mulberry leaf extract supplementation. Mulberry leaf extract had no effect on the UDP-glucuronyl transferase activity. Also, there was no significant difference in the level of liver cholesterol between the HC and mulberry leaf extract supplemented groups, while there was significant difference in the levels of liver total lipid and triglyceride. The HCM and HCH groups had more significant reduction in the activity of lipoprotein lipase in epididymal fat tissue than the HC group. The levels of total lipid, triglyceride and total cholesterol in epididymal fat tissue of HCL, HCM and HCH groups were decreased compared to HC group. The levels of total lipid, triglyceride and total cholesterol in feces from HCL, HCM and HCH groups were higher than those of HC group.


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