Development of Biologically Active Compounds from Edible Plant Sources - XXV. Immunostimulating Effect of Edible Plant Extracts

식용 식물자원으로부터 활성물질의 탐색 - XXV. 식용 식물 추출물의 면역증강 효과

  • Lyu, Ha-Na (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Park, Mi-Hyun (EromLife R&D Center, EromLife Co. Ltd.) ;
  • Hong, Seong-Gil (EromLife R&D Center, EromLife Co. Ltd.) ;
  • Lee, Dae-Young (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Han, Kyung-Min (Avixgen, Inc.) ;
  • Yoo, Jong-Su (Acupuncture and Meridianology Scientific Research Center, Kyung Hee University) ;
  • Kim, Se-Young (Institute of Life Science & Resources, Kyung Hee University) ;
  • Rho, Young-Duk (Institute of Life Science & Resources, Kyung Hee University) ;
  • Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
  • 류하나 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 박미현 (이롬라이프 생명과학연구원) ;
  • 홍성길 (이롬라이프 생명과학연구원) ;
  • 이대영 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 한경민 ((주)에빅스젠) ;
  • 유종수 (경희대학교 침구경락과학연구센터) ;
  • 김세영 (경희대학교 생명자원과학연구원) ;
  • 노영덕 (경희대학교 생명자원과학연구원) ;
  • 백남인 (경희대학교 생명공학원 및 식물대사연구센터)
  • Published : 2007.12.01


In this study, the 163 edible plants that are permitted as foods by the Korea Food and Drug Administration, were extracted in methanol. Following extration, their macrophage immunostimulating effects (MIE) were examined using a macrophage from BALB/C mice at four different concentrations of plant extract, such as $10\;{\mu}g/mL$, $100\;{\mu}g/mL$, $500\;{\mu}g/mL$, and $1,000\;{\mu}g/mL$, in vivo. Forty-two samples significantly showed MIEs. Among them, 20 samples had increased MIEs at higher than 10%, as compared to the negative control group. Nineteen samples had increased MIEs at two of the plant extract concentrations, and 3 samples [Allium schoenoprasmum (chive), Aralia elata (fatsia), Capsosiphon fulvescens (seaweed fulvescens)] had increased MIEs at three of the concentration conditions. In particular, Dioscorea batatas (yam) showed MIEs at all concentrations, as well as slightly higher MIEs as compared to the positive control group. Therefore, Dioscorea batatas was evaluated to be an excellent MIE.


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