Tissue Concentration of Quercetin, Isoquercitrin and Hyperoside, and Lipid Profile Changes Following 8-Week Feeding of Angelica keiskei Powder in Rats

백서에서 신선초 8주 투여에 의한 quercetin, isoquercitrin 및 hyperoside의 체내농도 및 혈중 지질함량 변화

  • Published : 2007.12.01


In this study, we examined the effects of Angelica keiskei (AK) in rats, in order to evaluate tissue quercetin concentrations and serum lipid profile changes. Dried AK powder was added to a regular chow at a 5% level, and fed for 8 weeks to male rats. AK significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol levels, while it increased high-density lipoprotein cholesterol levels. However, AK did not influence serum triglyceride levels. Two antioxidant flavonoids present in AK, quercetin and its glycoside isoquercitrin, were detected in the serum and liver of the rat. However, another quercetin glycoside, hyperoside, was not detected in either the serum or liver despite its presence in the diet. These results indicate that AK seems to alter serum lipid concentrations, possibly through the body's absorption of certain quercetin glycosides.


Angelica keiskei;quercetin;quercetin glycosides;rat;serum lipid profiles


  1. Park JC, Yu YB, Lee LH. Chemical components from the aerial parts of Angelica keiskei. Korean J. Pharmacogn. 27: 80-82 (1996)
  2. Hertog MGL, Hollman PCH, Van der Putte B. Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices. J. Agr. Food Chem. 41: 1242-1246 (1993) https://doi.org/10.1021/jf00032a015
  3. Hertog MGL, Hollman PCH, Van der Putte B. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agr. Food Chem. 40: 2397-2383 (1992)
  4. Chang Q, Zuo Z, Chow MS, Ho WK. Difference in absorption of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats. Eur. J. Pharm. Biopharm. 509: 549-555 (2005)
  5. Piskula MK, Terao J. Quercetin's solubility affects its accumulation in rat plasma after oral administration. J. Agr. Food. Chem. 46: 4313-4317 (1998) https://doi.org/10.1021/jf980117v
  6. Choi BG, Vilahur G, Viles-Gonzalez JF, Badimon JJ. The role of high-density lipoprotein cholesterol in atherothrombosis. Mt. Sinai J. Med. 73: 690-701 (2006)
  7. Hollman PCH, Kstan MB. Absorption, metabolism, and health effects of dietary flavonoids in man. Biomed. Pharmacother. 51: 305-310 (1997) https://doi.org/10.1016/S0753-3322(97)88045-6
  8. Kim JS, Kim HY, Park YK, Kim TS, Kang MH. The effects of green vegetable juice (Angelica keiskei) supplementation on plasma lipids and antioxidant status in smokers. Korean J. Nutr. 36: 933-941 (2003)
  9. Manach C, Morand C, Demigné C, Régérat F, Dimigné C, Rémésy C. Comparison of the bioavailability of quercetin and catechin in rats. Free Radical. Bio. Med. 27: 1259-1266 (1999) https://doi.org/10.1016/S0891-5849(99)00159-8
  10. Chang Q, Zhu M, Zuo Z, Chow M. High-performance liquid chromatographic method for simultaneous determination of hawthorn active compounds in rat plasma. J. Chromatogr. B 760: 227-235 (2001) https://doi.org/10.1016/S0378-4347(01)00273-0
  11. Chun SS, Park JC, Kim SH, Lee DY, Choi HM, Hwang EY. Changes in biologically active component of Angelica keiskei by cooking methods. J. Korean Soc. Food Sci. Nutr. 27: 121-125 (1998)
  12. Park JC, Cho YS, Park SK, Park JR, Jeon SS, OK KD, Choi JW. Isolation of flavone-7-O-glucosides from the aerial parts of Angelica keiskei and anti-hyperlipidemic effect. Korean J. Pharmacogn. 26: 337-373 (1995)
  13. Hertog MGL, Kromhaut D, Aravanis C, Blackburn H, Buzina R, Fidanza F, Giampaoli S, Jansen A, Menotti A. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med. 155: 381-386 (1995) https://doi.org/10.1001/archinte.155.4.381
  14. Shim JS, Kim SD, Kim TS, Kim KN. Biological activities of flavonoid glycosides isolated from Angelica keiskei. Korean J. Food Sci. Technol. 37: 78-83 (2005)
  15. Park JR, Park SK, Cho YS, Chun SS, Choi SH, Park JC. Effects of Angelica keiskei on lipid metabolism in rats. J. Korean Soc. Food Sci. Nutr. 26: 308-313 (1997)
  16. Merken HM, Beecher GR. Liquid chromatographic method for the separation and quantification of prominent aglycones. J. Chromatogr. A 897: 177-184 (2000) https://doi.org/10.1016/S0021-9673(00)00826-8