Identification of osteopontin in milk and in the mammary glands of cows

원유 및 젖샘조직 내 osteopontin의 동정

  • 강재윤 ((주)제주우유) ;
  • 김희철 (제주대학교 생명자원과학대학 수의학과) ;
  • 김동식 ((주)제주우유) ;
  • 지영흔 (제주대학교 생명자원과학대학 수의학과) ;
  • 신태균 (제주대학교 생명자원과학대학 수의학과)
  • Accepted : 2007.01.16
  • Published : 2007.03.30


The importance of milk for the growth and health of a newborn offspring is well known. Milkcontains immunoglobulin G (Ig G), Ig A, lactoperoxidase, lactoferin, cytokines, and growth factors.Osteopontin, one of the multifunctional proteins, is secreted by macrophages, T cel, and epithelial cells.bovine milk have not been clarified. The aim of this study was to observe the expression of osteopontin,in bovine milk during the lactation period or bovine mamary glands..Western blot analysis detected thatosteopontin was expressed in bovine milk whey and mamary glands. The expression level of osteopontinin colostrum whey was higher than those in early milk and mature milk whey. Immunohistochemistryshowed that osteopontin was detected in the glandular epithelium and epithelial cels of intralobular ductof mamary glands. These findings suggest that osteopontin transiently shows high expression in colostrumand plays a potential role in the immunological development of breast-fed calves.


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