Pathogenicity of Paenibacillus polymyxa JB115 and single-dose toxicity of its culture broth containing ${\beta}$-glucan in rats

Rat에서 Paenibacillus polymyxa JB115의 병원성 및 ${\beta}$-glucan 함유 배양산물에 대한 단회 경구독성시험

  • Accepted : 2007.10.05
  • Published : 2007.12.30

Abstract

This study was conducted to investigate the pathogenicity of Paenibacillus (R) polymyxa JB 115 and single oral dose toxicity of culture broth containing (${\beta}$-glucan (CBG-JB 115) produced from P. polymyxa JB 115 in Sprague-Dawely rats of both sexes for 14 days. After oral administration of P. polymyxa JB 115 into rats, we could not find any abnormal clinical signs and variation in the body weight and temperature as compared with control group. We also investigated the acute toxicity of CBG-JB 115. As the results, there were no clinical signs and variance in the body weight and temperature related with CBG-JB 115 in comparison with the control group. From the this experiment, we could not find out any significant pathogenicity and toxicity induced by P. polymyxa JB 115 or by CBG-JB 115. Results of this study demonstrated that consumption of P. polymyxa JB 115 and its culture broth containing (${\beta}$-glucan was not associated with any obvious signs of toxicity in Sprague-Dawely rats even following consumption of large quantities.

Acknowledgement

Supported by : 산업자원부

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