Antioxidative effects of Houttuynia cordata root on non-lipid oxidative damage

비 지질 산화손상에 대한 어성초 뿌리의 항산화 효과

  • Hah, Dae-Sik (Gyeongnam Livestock Promotion Institute Middle-branch) ;
  • Kim, Chung-Hui (Department of Animal Science and Biotechnology, Jinju National University) ;
  • Kim, Euikyung (College of Veterinary Medicine, Gyeongsang National University (Institute of Animal Science)) ;
  • Kang, Chung-boo (College of Veterinary Medicine, Gyeongsang National University (Institute of Animal Science)) ;
  • Kim, Jong-shu (College of Veterinary Medicine, Gyeongsang National University (Institute of Animal Science))
  • 하대식 (경상남도 축산진흥연구소 중부 지소) ;
  • 김충희 (진주산업대학교 동물생명과학과) ;
  • 김의경 (경상대학교 수의과대학 (동물의학연구소)) ;
  • 강정부 (경상대학교 수의과대학 (동물의학연구소)) ;
  • 김종수 (경상대학교 수의과대학 (동물의학연구소))
  • Accepted : 2007.03.15
  • Published : 2007.03.30

Abstract

Houttuynia cordata root on non-lipid oxidative damage. The antioxidative efects of methanolic (MeOH) extract of Houttuynia cordata rooton non-lipid, including liposome oxidation, oxidation of deoxyribose, protein oxidation, chelating, scavenging,and 2'-deoxyguanosine (2'dG) oxidation were investigated. Houttuynia cordata root exhibited highantioxidative effect in a liposome model system. The inhibitory effect of MeOH extract on deoxyribosedamage exhibited antioxidative effect and it afforded considerable protection against damage to deoxyribose.In addition, MeOH extract at over 300extracts exhibited metal binding ability for hydrogen peroxide. Furthermore, the oxidation of 2'dG to 8-hydroxy-2-deoxyguanosine was inhibited by MeOH extracts, and scavenging activity for hydroxyl radicalexhibited a remarkable effect. The present results on biological model systems showed that MeOH extractswas effective in the protection of non-lipids against various oxidative model systems.

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