Change of the Amylase Secretion on the Rat Submandibular Gland in the Restraint Stress Condition

구속스트레스에 의한 백서 악하선의 Amylase 분비 변화

  • Koo, Han-Mi (Dept. of Oral Medicine, College of Dentistry, Kyung Hee University) ;
  • Au, Q-Schick (Dept. of Oral Medicine, College of Dentistry, Kyung Hee University) ;
  • Chun, Yang-Hyun (Dept. of Oral Medicine, College of Dentistry, Kyung Hee University) ;
  • Hong, Jung-Pyo (Dept. of Oral Medicine, College of Dentistry, Kyung Hee University)
  • 구한미 (경희대학교 치과대학 구강내과학교실) ;
  • 어규식 (경희대학교 치과대학 구강내과학교실) ;
  • 전양현 (경희대학교 치과대학 구강내과학교실) ;
  • 홍정표 (경희대학교 치과대학 구강내과학교실)
  • Published : 2007.03.30


In currently, stress diseases are increased that present several sign and symptoms. Under stress condition, there are dry mouth, burning mouth syndrome, oral mucosa diseases and halitosis more frequently. Changing of salivary proportion is checked in almost patients with changing of function and structure in salivary gland. This study purpose are what effect stress does on salivary gland, and a-amylase on salivary gland. This study was resulted that 1. Under restraint stress, acinar cells are vacuolization and changing of intercellular spaces are separated, and peripheral tissues of duct are changed 2. Acinar cells were shrunk after 3 hours under restraint stress, intercellular space was separated after 6hours, peripheral tissues of duct started to change after 72 hours, and acinar cells and peripheral tissues of duct were all severely changed after 168hours. 3. In immunohistochemical study, amylase reaction was showed partially and irregularly after 3 hours, was getting little milder after 6 hours. And amylase reaction was gradually increased from the time of 12 hours after experiment up to the time of 48 hours after experiment. But after 168 hours, amylase appearance was diminished. According this result, emotional stress can change of salivary gland structure, and amylase secretion, the important digestive enzyme from salivary gland is changed and it is supposed to make digestive disorder and to make halitosis efficiency. So, we need to study about secretion of amylase.


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