Improvement of Maskless Photolithography of Bio Pattern with Single Crystalline Silicon Micromirror Array

DOI QR코드

DOI QR Code

Jang, Yun-Ho;Lee, Kook-Nyung;Park, Jae-Hyoung;Shin, Dong-Sik;Lee, Yoon-Sik;Kim, Yong-Kweon

  • 발행 : 2007.06.01

초록

This study focuses on the enhancement of maskless photolithography as well as the peptide synthesis application with single crystalline silicon micromirrors. A single crystalline silicon micromirror array has been designed and fabricated in order to improve its application to the peptide synthesis. A micromirror rotates about ${\pm}\;9^{\circ}$ at the pull-in voltage, which can range from 90.7 V to 115.1 V. A $210\;{\mu}m-by-210\;{\mu}m$ micromirror device with $270\;{\mu}m$ mirror pitch meets the requirements of an adequately precise separation for peptide synthesis. Synthetic 16 by 16 peptide array corresponds to the same number of micromirrors. The large size of peptide pattern and the separation facilitate biochip experiments using fluorescence assay. The peptide pattern has been synthesized on the GPTS-PEG200 surface with BSA-blocking and thereupon the background was acetylated to reject non-specific bindings. Hence, an averaged slope at the pattern edge has been distinguishably improved in comparison to patterning results from an aluminum micromirror.

키워드

Aluminum Micromirror;Averaged Slope;GPTS-PEG200;Peptide Synthesis;Single Crystalline Silicon Micromirror Array

참고문헌

  1. S. Singh-Gasson, R. Green, Y. Yue, C. Nelson, F. Blattner, M. R. Sussman and F. Cerrina, 'Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array' Nature Biotechnol., vol. 17, pp. 974–78, 1999
  2. I. W. Jung, J. S. Wang, and O. Solgaard, 'Spatial light modulators for maskless lithography' in Proc. IEEE Int. Conf. on MOEMS'6, Montana, U.S.A., Aug. 21- 24 2006, pp. 150-151
  3. K. N. Lee, D. S. Shin, Y. S. Lee and Y. K. Kim, 'Protein patterning by virtual mask photolithography using a micromirror array' J. Micromech. Microeng., vol. 13, no.1, pp.18-25, 2003 https://doi.org/10.1088/0960-1317/13/1/303
  4. K. N. Lee, D. S. Shin, Y. S. Lee and Y. K. Kim, 'Micromirror array for protein micro array fabrication' J. Micromech. Microeng., vol. 13, no. 3, pp. 474-481, 2003 https://doi.org/10.1088/0960-1317/13/3/318
  5. L.J. Hornbeck, 'Deformable-mirror spatial light modulators,'Spatial Light Modulators and Applications III, SPIE Critical Reviews, vol. 1150, pp. 86-102, 1989
  6. Y. H. Jang, K. N. Lee, and Y. K. Kim, 'Characterization of a single-crystal silicon micromirror array for maskless UV lithography in biochip applications' J. Micromech. Microeng., vol. 16, no. 11, pp. 2360-2368, 2006 https://doi.org/10.1088/0960-1317/16/11/016
  7. D. S. Shin, K. N. Lee, K. H. Jang, J. K. Kim, W. J. Chung, Y. K. Kim, and Y. S. Lee, 'Protein patterning by maskless photolithography on hydrophilic polymer-grafted surface' Biosens. Bioelectron., vol. 19, pp. 485-494, 2003 https://doi.org/10.1016/S0956-5663(03)00228-8

피인용 문헌

  1. 1. A low-drift, open-loop controlled, single crystalline silicon micromirror with floating field-limiting shields vol.18, pp.3, 2008, doi:10.5370/JEET.2007.2.2.274
  2. 2. Pull-in voltage uniformity analysis of digitally operated micro mirror array with torsional springs vol.19, pp.3, 2009, doi:10.5370/JEET.2007.2.2.274