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Inhibitory Effects of Soyeum Pharmacopuncture (SPP) on Rheumatoid Arthritis in Collagen II-induced Arthritis (CIA) Mice

소염약침액이 Collagen II 유발 관절염 mouse의 TNF-α, IFN-γ 생성 및 비장세포 증식에 미치는 영향

  • Yoo, Hwa-Seung (East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Youn, Dae-Hwan (Department of Meridian and Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University) ;
  • Lim, Jong-Soon (Institute of Traditional Medicine and Bioscience, Daejeon University)
  • 유화승 (대전대학교 한의과대학 동서암센터) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 김승형 (대전대학교 동서생명과학연구원) ;
  • 임종순 (대전대학교 동서생명과학연구원)
  • Published : 2007.06.30

Abstract

Objective : The aim is to examine the effect of Soyeum Pharmacopuncture (SPP) on collagen-induced arthritis (CIA) in DBA/1OlaHsd mice. Methods : To determine the effect of SPP on chronic IFNlammatory joint disease, we induced CIA in DBA/1OlaHsd mice by immunization with bovine type II collagen. Animals were treated with intraperitoneal injection doses of 2 mg/kg of SPP, beginning 3 days before the expected onset of disease symptoms. Inhibitory Effects of SPP were observed by serum levels of TNF-${\alpha}$, and IFN-${\gamma}$,,, or cell proliferation in the spleen cell culture and histological examination of knee joint. Results : In the CIA Mice, serum levels of TNF-${\alpha}$, and IFN-${\gamma}$,, production in the spleen cell culture were reduced. At the histopathological examination of knee joint, chondropathy of cartilage in the synovial joint in the SP group was repaired while compared with control group. Conclusion : These results suggest that the SPP may be effective for the prevention and treatment of rheumatoid arthritis disease.

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