Malignant aortic body tumor in a Korean Jindo dog

  • Accepted : 2007.08.30
  • Published : 2007.09.30

Abstract

A 7-year-old, intact female Korean Jindo dog was referred due to ataxia and pain on palpation of the thorax. Radiograph, echocardiography and computed tomogram revealed a mass on the heart base region and osteolytic change of fifth thoracic (T5) vertebra. At necropsy, a firm, encapsulated and round mass was seen arising from the heart base region surrounding the ascending aorta and pulmonary artery. Histopathologically, nests of cuboidal and polyhedral cells having abundantly granular and eosinophilic cytoplasm with round to oval nucleus were separated by fibrous septa. Immunohistochemistry using chromogranin A revealed that tumor cells were originated from neuroendocrine organ and metastasized into some organs including lung, spleen, liver, kidney and T5 vertebra. By electron microscopy, we found the electron-dense and membrane-bound granules in cytoplasm of the tumor cells. This study provides the uncommon evidence that aortic body tumor metastasized to both multiple organs and bone.

References

  1. Kimura N, Sasano N, Yamada R, Sotoh. J. Immunohistochemical study of chromogranin in 100 cases of phaeochromocytoma, carotid body tumour, medullary thyroid carcinoma and carcinoid tumor. Virchows Arch A Pathol Anat Histopathol 1988, 413, 33-38 https://doi.org/10.1007/BF00844279
  2. Patnaik AK, Lord PF, Liu SK. Chemodectoma of the urinary bladder in a dog. J Am Vet Med Assoc 1974, 164, 797-800
  3. Szczech GM, Blevins WE, Carlton WW, Cutlan GR. Chemodectoma with metastasis to bone in a dog. J Am Vet Med Assoc 1973, 162, 376-378
  4. Hayes HM, Sass B. Chemoreceptor neoplasia: A study of the epidemiological features of 357 canine cases. Zentralbl Veterinanned A 1988, 35, 401-408 https://doi.org/10.1111/j.1439-0442.1988.tb00052.x
  5. Doss JC, Grone A, Capen CC, Rosol TJ. Immunohistochemical localization of chromogranin A in endocrine tissues and endocrine tumors of dogs. Vet Pathol 1998, 35, 312-315 https://doi.org/10.1177/030098589803500413
  6. Vicari ED, Brown DC, Holt DE, Brockman DJ. Survival times of and prognostic indicators for dogs with heart base masses: 25 cases (1986- I 999). J Am Vet Med Assoc 2001, 219, 485-487 https://doi.org/10.2460/javma.2001.219.485
  7. Yates WDG, Lester SJ, Mills JHL. Chemoreceptor tumors diagnosed at the Western College of Veterinary Medicine 1967-1979. Can Vet J 1980, 21, 124-129
  8. Blackmore J, Gorman NT, Kagan K, Hines S, Spencer C. Neurologic complications of a chemodectoma in a dog. J Am Vet Med Assoc 1984, 184, 475-478
  9. Carlisle CR, Kelly WR, Samuel J, Robins GM. Spinal cord compression caused by a metastatic lesion from an aortic body tumour. Aust Vet J 1978, 54, 311-313 https://doi.org/10.1111/j.1751-0813.1978.tb02469.x
  10. Alleman AR. Endocrine system. In: Raskin RE, Meyer DJ (eds.). Atlas of the Canine and Feline Cytology. 1st ed. pp. 385-399, Saunders, Philadelphia, 2001
  11. Kurtz HJ, Finco DR. Carotid body and aortic body tumors in a dog-A case report. Am J Vet Res 1969, 30, 1247-1251
  12. Paltrinieri S, Riccaboni P, Rondena M, Giudice C. Pathologic and immunohistochemical findings in a feline aortic body tumor. Vet Pathol 2004, 41, 195-198 https://doi.org/10.1354/vp.41-2-195
  13. Kim SK, Hyun CB, Cho KO. Unusual metastasis of malignant aortic body tumor to multiple bones in a dog. J Vet Med Sci 2005, 67, 625-627 https://doi.org/10.1292/jvms.67.625
  14. Brown PJ, Rema A, Gartner F. Immunohistochemical characteristics of canine aortic and carotid body tumours. J Vet Med A Physiol Pathol Clin Med 2003, 50, 140-144 https://doi.org/10.1046/j.1439-0442.2003.00498.x
  15. Montgomery DL, Bendele R, Storts RW. Malignant aortic body tumor with metastasis to bone in a dog. Vet Pathol 1980, 17, 241-244 https://doi.org/10.1177/030098588001700214
  16. Dean MJ, Strafuss AC. Carotid body tumors in the dog: A review and report of four cases. J Am Vet Med Assoc 1975, 166, 1003-1006