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Anti-atherogenic Effect of Green Tea Product through Hypolipidemic and Anti-oxidative Action in Ovariectomized Rats

난소절제 흰쥐에서 녹차가공품의 지질강하와 항산화 작용을 통한 항동맥경화 효과

  • Cho, Mi-Kyung (School of Food and Life Sciences, Food Science Institute, and Biohealth Product Research Center) ;
  • Noh, Kyung-Hee (School of Food and Life Sciences, Food Science Institute, and Biohealth Product Research Center) ;
  • Kim, Jin-Ju (School of Food and Life Sciences, Food Science Institute, and Biohealth Product Research Center) ;
  • Song, Young-Sun (School of Food and Life Sciences, Food Science Institute, and Biohealth Product Research Center)
  • 조미경 (인제대학교 의생명공학대학 식품생명과학부, 식품과학연구소 및 바이오헬스 소재 연구센터) ;
  • 노경희 (인제대학교 의생명공학대학 식품생명과학부, 식품과학연구소 및 바이오헬스 소재 연구센터) ;
  • 김진주 (인제대학교 의생명공학대학 식품생명과학부, 식품과학연구소 및 바이오헬스 소재 연구센터) ;
  • 송영선 (인제대학교 의생명공학대학 식품생명과학부, 식품과학연구소 및 바이오헬스 소재 연구센터)
  • Published : 2007.10.30

Abstract

This study was carried out to investigate the effect of green tea product (GTP) on the risk factors of atherosclerosis in ovariectomized (OVX) rats. Sprague-Dewley female rats (10 weeks) weighing approximately $279{\pm}2g$ were divided into 4 groups: sham operated control group treated with high cholesterol diet (Sham-C), OVX control group treated with high cholesterol diet (OVX-C), OVX-G 5% group treated with high cholesterol containing 5% GTP and OVX-G 20% group treated with high cholesterol diet containing 20% GTP. Serum TG concentrations was lower in OVX-G 20% group than in the OVX-C group, whereas ratio of HDL-cholesterol to total cholesterol (%) was significantly (p<0.05) increased in the 20% GTP supplementation group than in the Sham-C and OVX-C groups. Tumor necrosis $factor-{\alpha}$ levels were significantly (p<0.05) decreased in the OVX-G 20% group. Hepatic TG levels were significantly (p<0.05) lowered in OVX-G 20% group than in the other groups. Glutathione levels and antioxidant enzyme activities including glutathione-reductase and Mn-superoxide dismutase in liver were significantly (p<0.05) higher in the OVX-G 20% group in the OVX-C group. Fecal total cholesterol concentrations were increased in the GTP supplementation groups than in the OVX-C group. From the above results, it is concluded that GTP may reduce the risk of atherosclerosis via hypolipidemic action. Therefore, it may be used to possibly improve the hyperlipemia in menopausal women.

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