Comparison of the Anti-inflammatory Effects of the Extracts from Rubus coreanus and Rubus occidentalis

토종 복분자와 외래종 복분자 추출물의 항염증효과 비교

  • Yang, Hyun-Mo (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Lim, Soon-Sung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Lee, Yeon-Sil (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Shin, Hyun-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Oh, Yang-Seok (Department of Medical Genetics, Hallym University) ;
  • Kim, Jin-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
  • 양현모 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 임순성 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 이연실 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 신현경 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터) ;
  • 오양석 (한림대학교 의학유전학교실) ;
  • 김진경 (한림대학교 식의약품의 효능평가 및 기능성소재개발센터)
  • Published : 2007.06.30

Abstract

The dried fruit of the Rubus coreanus, which is well-known in Korea and referred to as 'Bokbunja,' has been employed as a traditional medicine for centuries. This crude drug has been utilized in Korea for the management of impotence, spermatorrhea, enuresis, asthma, and allergic diseases. Our previous study demonstrated that the ethanol extracts of R. coreanus have anti-inflammatory effects. The principal objective of the present study was to conduct a comparison of the anti-inflammatory effects of the ethanol extracts of R. coreanus and R. occidentalis; here, we tested the unripe (URCE), half-ripened (HRCE), and ripened fruits (RCE) of R. coreanus, and the unripe (UROE), half-ripened (HROE), and ripened fruits (ROE) of R. occidentalis. We found that URCE, UROE, HRCE, and HROE reduced the production of nitric oxide and prostaglandin $E_{2}$ as well as pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW264.7 murine macrophages. Interestingly, the R. coreanus extracts showed stronger inhibitory effects on the production of these inflammatory mediators than the R. occidentalis extracts.

Keywords

Rubus coreanus;nitric oxide;prostaglandin $E_{2}$;pro-inflammatory cytokines;macrophages

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