Fourteen-day Repeated-dose Oral Toxicity Study of the Ethanol Extracts Isolated from Oplopanax elatus in Sprague-Dawley Rat

흰쥐에서 땃두릅 에탈올 추출물의 14일 반복경구토여에 의한 독성시험

  • Kwon, Hyuck-Se (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Kim, Dae-Hwan (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Shin, Hyun-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Yu, Chang-Yeon (College of Agriculture and Life Science, Kangwon National University) ;
  • Kim, Myong-Jo (College of Agriculture and Life Science, Kangwon National University) ;
  • Lim, Jung-Dae (Department of Pharmacognosy Material Development, Kangwon National University) ;
  • Park, Jae-Kun (Young Dong Functional Food Co., Ltd) ;
  • Kim, Jin-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
  • 권혁세 (한림대학교 식의약품의 효능평가 및 기능성소재 개발센터) ;
  • 김대환 (한림대학교 식의약품의 효능평가 및 기능성소재 개발센터) ;
  • 신현경 (한림대학교 식의약품의 효능평가 및 기능성소재 개발센터) ;
  • 유창연 (강원대학교 농업생명과학대학 식물자원응용학과) ;
  • 김명조 (강원대학교 농업생명과학대학 식물자원응용학과) ;
  • 임정대 (강원대학교 생약자원개발학과) ;
  • 박재군 ((주)영동기능식품) ;
  • 김진경 (한림대학교 식의약품의 효능평가 및 기능성소재 개발센터)
  • Published : 2007.08.31

Abstract

Oplopanax elatus (O. elatus) is a tall deciduous shrub that has traditionally been used for σ eating a variety of ailments such as diabetes, coughling, rheumatism, gastro-intestinal disorders, and wounds. In order to examine the safety of the ethanol extracts of O. elatus, we performed a 14-day repeated-dose toxicity study with Sprague-Dawley rats. The rats were treated with daily doses of the D. elatus ethanol extracts by gavage at 0, 500, 1000, and 2000 mg/kg/day for 14 consecutive days. We recorded clinical signs of toxicity, body weight, hematology, organ weights, gross and histological changes in target organs, and clinical chemistry analysis data for all rats. There were no significant changes in body and organ weights during the experimental period. The hematological analysis and clinical blood chemistry data revealed no toxic effects from the O. elatus ethanol extracts. Pathologically, neither gross abnormalities nor histopathological changes were observed between the control and treated rats of both sexes. Collectively, these data suggest that the ethanol extracts of O. elatus have a high margin of safety.

Keywords

Oplopanax elatus;14-day repeated-dose oral toxity;SD rat

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