DOI QR코드

DOI QR Code

Lipid Lowering Effect of Anthocyanin-Pigmented Rice Bran in Streptozotocin-Induced Diabetic Male Rats

  • Han, Hae-Kyoung (Department of Foods and Nutrition, DukSung Women's University) ;
  • Choi, Sung-Sook (Department of Foods and Nutrition, DukSung Women's University) ;
  • Shin, Jin-Chul (National Crop Experiment Station, Rural Development Administration) ;
  • Chung, Ha-Sook (Department of Foods and Nutrition, DukSung Women's University)
  • Published : 2008.12.31

Abstract

Oryza sativa cv. Heugjinjubyeo, an anthocyanin-pigmented rice variety, is well known to contain high levels of bioactive phytochemicals, anthocyanin, quinolone alkaloids and phenolic acids. Here, we studied the inhibitory effect of Oryza sativa cv. Heugjinjubyeo bran on the absorption of dietary fat in streptozotocin-induced diabetic Sprague-Dawley male rats. For these experiments, experimental animals were divided into four groups: normal, diabetic-control and two experimental groups that were fed 1.0 g or 2.0 g/kg body weight/day of Oryza sativa cv. Heugjinjubyeo bran supplement for 14 days. As a result, liver glycogen levels increased significantly by 65% and 32% in groups receiving 1.0 g and 2.0 g/kg body weight/day, respectively, compared to diabetic-control. Liver cholesterol levels were significantly lower by 8.3% and 14.5% in the groups fed 1.0 g and 2.0 g of anthocyanin- pigmented rice extracts, respectively.

References

  1. Chung HS, Han HK, Ko JH, Shin JC. 2001. Effect of the aleurone layer of anthocyanin-pigmented rice on blood glucose and lipid metabolism in streptozotocin induced diabetic rats. J Food Sci Nutr 3: 176-179
  2. Chung HS, Woo WS. 2001. A quinolone alkaloid with antioxidant activity from the aleurone layer of anthocyanin-pigmented rice. J Nat Prod 64: 1579-1580 https://doi.org/10.1021/np010324g
  3. Hyun JW, Chung HS. 2004. Cyanidin and malvidin from Oryza sativa cv. Heugjinjubyeo mediate cytotoxicity against human monocytic leukemia cells by arrest of G2/M phase and induction of apoptosis. J Agric Food Chem 52: 2213-2217 https://doi.org/10.1021/jf030370h
  4. Chung HS, Shin JC. 2007. Characterization of antioxidant alkaloids and phenolic acids from anthocyanin-pigmented rice (Oryza sativa cv. Heugjinjubyeo). Food Chem 104: 1670-1677 https://doi.org/10.1016/j.foodchem.2007.03.020
  5. King H, Rewers M. 1993. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. Diabetes Care 16: 157-177 https://doi.org/10.2337/diacare.16.1.157
  6. Hunt JV, Wolff SP. 1991. Oxidative glycation and free-radical production-a causal mechanism of diabetic complications. Free Radic Res Commun 12-13(Pt 1): 115-123 https://doi.org/10.3109/10715769109145775
  7. Larner J. 1985. Insulin and oral hypoglycaemic drugs, glucagon. In The Pharmacological basic of therapeutics. Gilman AG, Goodman LS, Rall TW, Murad F, eds. Mcmillan, New York. Vol. 7, p 1490
  8. Monin A. 1987. Role of indigenous medicine in primary health care. Proceedings of first international seminar on Unani Medicine. New Delhi, India. p 54
  9. Hassid WZ, Abraham X. 1957. Chemical procedures for analysis polysaccharides. In Methods in enzymology. Colowick SP, Kaplan NO, eds. Academic Press, New York. Vol. 3, pp 34-37
  10. Giegel JL, Ham SB, Clema W. 1975. Serum triglyceride determined colorimetry with an enzyme that produces hydrogen peroxide. Clin Chem 21: 1575-1581
  11. lesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 19: 1350-1356
  12. Uchiyama M, Mihara M. 1978. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86: 271-278 https://doi.org/10.1016/0003-2697(78)90342-1
  13. Lowry OH, Rosebrough NF, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-273
  14. Ku DD, Sellers BM, Meezan E. 1986. Development of renal hypertrophy and increase renal Na, K-ATPase in streptozotocin-diabetic rats. Endocrinol 119: 672-679 https://doi.org/10.1210/endo-119-2-672
  15. Kedziora-Kornatowska K, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kedziora JB. 2002. The effect of verapamil on the antioxidant defense system in diabetic kidney. Clin Chim Acta 322: 105-112 https://doi.org/10.1016/S0009-8981(02)00167-5
  16. Tschope C, Reinecke A, Seidl U, Yu M, Gavriluk V, Riester U, Gohlke P, Graf K, Bader M, Hilgenfeldt U, Pesquero JB, Ritz E, Unger T. 1999. Functional, biochemical and molecular investigations of renal kallikrein-kinin system in diabetic rats. Am J Physiol 277: 2333-2340
  17. Yang YR, Kim HL, Park YK. 2008. Effects of onion kimchi extract supplementation on blood glucose and serum lipid contents in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 37: 445-451 https://doi.org/10.3746/jkfn.2008.37.4.445
  18. Grover JK, Vats V, Rathi SS, Dawar R. 2001. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J Ethnopharmcol 76: 233-238 https://doi.org/10.1016/S0378-8741(01)00246-X
  19. Hornbrook KR. 1970. Synthesis of liver glycogen in starved alloxan diabeic rats. Diabetes 19: 916-923 https://doi.org/10.2337/diab.19.12.916
  20. Migliorini RH. 1971. Early changes in the levels of liver glycolytic enzymes after total pnceratectomy in the rat. Biochim Biophys Acta 244: 125-128 https://doi.org/10.1016/0304-4165(71)90128-0
  21. Whitton PD, Hems DA. 1975. Glycogen synthesis in the perfused liver of streptozotocin-diabetic rats. Biochem J 150:153-165 https://doi.org/10.1042/bj1500153
  22. Bishop JS. 1970. Inability of insulin to activate liver glycogen transferase D phosphatase in the diabetic pancreatectomized dog. Biochim Biophys Acta 208: 208-218 https://doi.org/10.1016/0304-4165(70)90239-4
  23. Tan AW, Nuttall FQ. 1976. Regulation of synthase phosphatase and phosphorylase in rat liver. Biochim Biophys Acta 445: 118-130 https://doi.org/10.1016/0005-2744(76)90165-0
  24. Golden S, Wals PA, Okajima F, Katz J. 1979. Glycogen synthesis by hepatocytes from diabetic rats. Biochem J 182: 727-734 https://doi.org/10.1042/bj1820727
  25. Singh SN, Vats P, Suri S, Shyam R, Kumria MM L, Ranganathan S, Sridharan K. 2001. Effect of antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. J Ethnopharmacol 76: 269-277 https://doi.org/10.1016/S0378-8741(01)00254-9
  26. O'meara NM, Devery RA, Owens D, Collins PB. 1990. Cholesterol metabolism in alloxan-induced diabetic rabbits. Diabetes 39: 626-633 https://doi.org/10.2337/diabetes.39.5.626
  27. Nikkail EA, Hormila P. 1978. Serum lipids and lipoproteins in insulin-treated diabetes demonstration of increased high-density lipoprotein concentration. Diabetes 27: 1078-1086 https://doi.org/10.2337/diab.27.11.1078
  28. Beach KW, Brunzell JD, Conquest LL, Strandness DE. 1979. The correlation of arteriosclerosis obliterans with lipoproteins, in insulin-dependent and non insulin-dependent diabetes. Diabetes 28: 836-840 https://doi.org/10.2337/diab.28.9.836
  29. Abrams JJ, Ginberg H, Grudy SM. 1982. Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus. Diabetes 31: 903-910 https://doi.org/10.2337/diabetes.31.10.903
  30. Ausman LM, Rong N, Nicolosi RJ. 2005. Hypocholesterolemic effect of physically refined rice bran oil: Studies of cholesterol metabolism and early atherosclerosis in hypercholesterolemic hamsters. J Nutr Biochem 16: 521-529 https://doi.org/10.1016/j.jnutbio.2005.01.012
  31. Kempaiah RK, Srinivasan K. 2006. Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats. J Nutr Biochem 17: 471-478 https://doi.org/10.1016/j.jnutbio.2005.09.005
  32. Rodriguez de Sotillo DV, Hadley M. 2002. Chlorogenic acid modifies plasma and liver concentrations of cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats. J Nutr Biochem 13: 717-726 https://doi.org/10.1016/S0955-2863(02)00231-0
  33. Wilson TA, Nicolosi RJ, Woolfrey B, Kritchevsky D. 2007. Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. J Nutr Biochem 18: 105-112 https://doi.org/10.1016/j.jnutbio.2006.03.006
  34. Kakkar R, Mantha SV, Radhi J, Prasad K, Kalra J. 1998. Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes. J Clin Sci 94: 623-632 https://doi.org/10.1042/cs0940623
  35. Sato Y, Hotto N, Sakamoto N, Matsuoka S, Ohishi N, Yafi K. 1979. Lipid peroxide level in plasma of diabetic patients. Biochem Med 2: 104-107 https://doi.org/10.1016/0006-2944(79)90061-9
  36. Kakkar R, Kalra J, Mantha SV, Prasad K. 1995. Lipid peroxidation and activity of antioxidant enzymes in diabetic rats. Mol Cell Biochem 151: 113-119 https://doi.org/10.1007/BF01322333
  37. Gougeon R, Pencharz PB, Marliss EB. 1995. Protein metabolism in diabetes mellitus: Implications for clinical management. In Diabetes Cowett RM. ed. New York, Raven. pp 241-258
  38. Eidi A, Eidi M, Esmaeili E. 2006. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 13: 624-629 https://doi.org/10.1016/j.phymed.2005.09.010

Cited by

  1. Phenolic Compounds and Bioactivities of Pigmented Rice vol.53, pp.3, 2013, https://doi.org/10.1080/10408398.2010.529624