DOI QR코드

DOI QR Code

Cherry Tomatoes Ameliorate Scopolamine-induced Amnesia in Mice

  • Choi, Won-Hee (Functional Food Technology Research Center, Korea Food Research Institute) ;
  • Ahn, Ji-Yun (Functional Food Technology Research Center, Korea Food Research Institute) ;
  • Kim, Su-Na (Functional Food Technology Research Center, Korea Food Research Institute) ;
  • Ha, Tae-Youl (Functional Food Technology Research Center, Korea Food Research Institute)
  • Published : 2008.12.31

Abstract

Cherry tomatoes are rich in antioxidants, which may protect against neurodegeneration and consequent memory loss. This study was conducted to investigate the effect of cherry tomatoes on scopolamine-induced amnesia in mice. Male ICR mice (4 weeks old) were maintained for 4 weeks on a diet containing 10 or 20% tomato powder (TP), and then administered scopolamine (1 mg/kg body weight, i.p.) 45 min before memory testing. Passive avoidance and Morris water maze testing revealed that scopolamine-induced amnesia was significantly reduced in the TP groups compared to the non TP-received (control) group. Accordingly, acetylcholinesterase activities in the serum and brain of TP groups were lower than those in the control group. These findings suggest that cherry tomatoes may be useful for the prevention of neurodegenerative diseases such as amnesia and Alzheimer's disease.

References

  1. Beatty WW, Butters N, Janowsky D. 1986. Memory failure after scopolamine treatment: implications for cholinergic hypothesis of dementia. Behav Neural Biol 45: 196-211 https://doi.org/10.1016/S0163-1047(86)90772-7
  2. Jones GMM, Sahakian BJ, Levy R, Warburton DM, Gray JA. 1992. Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology 108: 485-494 https://doi.org/10.1007/BF02247426
  3. Eidi M, Zarrindast MR, Eidi A, Oryan S, Parivar K. 2003. Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats. Eur J Pharmacol 465: 91-96 https://doi.org/10.1016/S0014-2999(03)01440-7
  4. Dunnett SB, Toniolo G, Fine A, Ryan CN, Bjorklund A, Iversen SD. 1985. Transplantation of embryonic ventral forebrain neurons to the nucleus basalis magnocellularis: II. Sensorimotor and learning impairments. Neuroscience 16: 787-797 https://doi.org/10.1016/0306-4522(85)90094-6
  5. Levy ML, Cummings JL, Kahn-Rose R. 1999. Neuropsychiatric symptoms and cholinergic therapy for Alzheimer's disease. Gerontol 45: 15-22 https://doi.org/10.1159/000052760
  6. Musial A, Bajda M, Malawska B. 2007. Recent develop ments in cholinesterases inhibitors for Alzheimer's disease treatment. Curr Med Chem 14: 2654-2679 https://doi.org/10.2174/092986707782023217
  7. Zhong CB, Pan YP, Tong XY, Xu XH, Wang XL. 2005. Delayed rectifier potassium currents and Kv2.1 mRNA increase in hippocampal neurons of scopolamine-induced memory-deficient rats. Neurosci Lett 373: 99-104 https://doi.org/10.1016/j.neulet.2004.09.069
  8. Ebert U, Kirch W. 1998. Scopolamine model of dementia: electroencephalogram findings and cognitive performance. Eur J Clin Invest 28: 944-949 https://doi.org/10.1046/j.1365-2362.1998.00393.x
  9. Collerton D. 1986. Cholinergic function and intellectual decline in Alzheimer's disease. Neuroscience 19: 1-28 https://doi.org/10.1016/0306-4522(86)90002-3
  10. Heber D, Lu QY. 2002. Overview of mechanisma of action of lycopene. Exp Bio Med 227: 920-923 https://doi.org/10.1177/153537020222701013
  11. Rao AV, Agarwal S. 2000. Role of antioxidant lycopene in cancer and heart disease. J Am Coll Nutr 19: 563-569 https://doi.org/10.1080/07315724.2000.10718953
  12. Bhuvaneswari V, Nagini S. 2005. Lycopene: a review of its potential as an anticancer agent. Curr Med Chem Anticancer Agents 5: 627-635 https://doi.org/10.2174/156801105774574667
  13. Rao AV, Ray MR, Rao LG. 2006. Lycopene. Adv Food Nutr Res 51: 99-164 https://doi.org/10.1016/S1043-4526(06)51002-2
  14. George B, Kaur C, Khurdiya DS, Kapoor HC. 2004. Antioxidant in tomato (Lycopene esculentum) as a function of genotype. Food Chem 84: 45-51 https://doi.org/10.1016/S0308-8146(03)00165-1
  15. Morris RG. 1984. Development of water maze procedure for studying spatial learning in the rat. J Neurosci Methods 11: 47-60 https://doi.org/10.1016/0165-0270(84)90007-4
  16. Ellman GL, Courtney KD, Andres VJ, Featherstone RM. 1961. A new and rapid colormetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88-95 https://doi.org/10.1016/0006-2952(61)90145-9
  17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1993. Protein measurement with Folin phenol reagent. J Biol Chem 193: 265-275
  18. Kim DH, Kim DY, Kim YC, Jung JW, Lee SJ, Yoon BH, Cheong JH, Kim YS, Kang SS, Ko KH, Ryu JH. 2007. Nodakain, a coumarin compound, ameliorates scopolamine-induced memory disruption in mice. Life Sci 80: 1944-1950 https://doi.org/10.1016/j.lfs.2007.02.023
  19. Fan Y, Hu JF, Li J, Yang Z, Xin XL, Wang J, Ding J, Geng MY. 2005. Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms. Neurosci Lett 374: 222-226 https://doi.org/10.1016/j.neulet.2004.10.063
  20. Levy AI. 1996. Muscarinic acetylcholine receptor expression in memory circus; implications for treatment of Alzheimer disease. Proc Natl Acad Sci 93: 13541-13546 https://doi.org/10.1073/pnas.93.24.13541
  21. Cutler NR, Stramelk JJ. 2001. Review of the next generation of Alzheimer's disease therapeutics; challenges for drug development. Prog Neuropsychopharmacol Biol Psychiatry 25: 27-57 https://doi.org/10.1016/S0278-5846(00)00147-0
  22. Ezio G. 1998. Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrines to future applications. Neurochem Int 32: 413-419 https://doi.org/10.1016/S0197-0186(97)00124-1
  23. Siddiqui MF, Levey AI. 1999. Cholinergic therapies in Alzheimer's disease. Drug Future 24: 417-444 https://doi.org/10.1358/dof.1999.024.04.668318
  24. Aust O, Sies H, Atahl W, Polidory MC. 2001. Analysis of lipophilic abtioxidants in human serum and tissues: tocopherols and carotenoids. J Chromatogr 936: 83-93 https://doi.org/10.1016/S0021-9673(01)01269-9
  25. Rao AV, Agarwal S. 1999. Role of lycopene as antioxidant carotenoid in the prevention of chronic disease: a review. Nutr Res 19: 305-323 https://doi.org/10.1016/S0271-5317(98)00193-6
  26. Clinton SK. 2000. Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev 56: 35-51 https://doi.org/10.1111/j.1753-4887.1998.tb01691.x
  27. Emilla AM M, Resina LM, F, Danilo WF, Daniela N, Fabiola S, France B, Emil K. 2005. Effects of diet energy level and tomato powder consumption on antioxidant status in rats. Clin Nutr 24: 1038-1046 https://doi.org/10.1016/j.clnu.2005.08.005
  28. Lee SY, Son DH, Ha TY, Hong JT. 2005. Protective effect of sesaminol glucosides on memory impairment and ${\beta}$, ${\gamma}$-secretase activity in vivo. Yahhak Hoeji 49: 168-173

Cited by

  1. The Aqueous Extract of Rubus coreanus Miquel Improves Scopolamine-Induced Memory Impairment in ICR Mice vol.41, pp.2, 2012, https://doi.org/10.3746/jkfn.2012.41.2.192