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The Study of Doxorubicin and its Interaction with Adenine by UV-Resonance Raman Spectroscopy

자외선 공명 라만분광법을 이용한 Doxorubicin과 Adenine의 상호작용 연구

  • Published : 2008.04.20

Abstract

The interaction of the antitumour agent, doxorubicin, with adenine is investigated in an aqueous solution at a concentration of 10-3~10-4 with volume ratios of 1:2. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the binding sites of doxorubicin to adenine and the structural variations of doxorubicin-adenine complexes in an aqueous solution. We identified that the possibilities of doxorubicin interacted with the N7 positions of adenine.

Keywords

References

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