Effects of Enzymatic Hydrolysates from Hamcho (Salicornia herbacea L.) on Blood Glucose and Serum Lipid Composition in Streptozotocin-Induced Diabetic Rats

함초(Salicornia herbacea)의 효소적 가수분해물이 스트렙토조토신-유발 당뇨쥐의 혈당 강하 및 혈청 지질 개선효과

  • Kim, Kyung-Ran (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Choi, Jeong-Hwa (School of Food Science, Jinju International University) ;
  • Woo, Mi-Hee (College of Pharmacy, Catholic University of Daegu) ;
  • Kim, Young-Hee (Dept. of Hotel Culinary Art, Yangsan College) ;
  • Choi, Sang-Won (Dept. of Food Science and Nutrition, Catholic University of Daegu)
  • 김경란 (대구가톨릭대학교 식품영양학과) ;
  • 최정화 (진주국제대학교 식품과학부) ;
  • 우미희 (대구가톨릭대학교 약학과) ;
  • 김영희 (양산대학 호텔조리과) ;
  • 최상원 (대구가톨릭대학교 식품영양학과)
  • Published : 2008.02.29


This study was designed to investigate the effects of enzymatic hydrolysates (EH) from Hamcho (Salicornia herbacea L.) on blood glucose and serum lipid status in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into normal and 5 diabetic groups. The diabetic groups were fed enzymatic hydrolysate-free control (DM) diets or diets supplemented with 0.02% (DM-2), 0.04% (DM-4), 0.08% (DM-8), and 0.16% (DM-16) of enzymatic hydrolysate for 4 weeks. Body weight gains were lower in five diabetic groups than that of the normal group. Blood glucose was decreased in EH-supplemented groups as compared to the normal group, and especially the lowest blood glucose levels were found in DM-4 and DM-8 groups. Activities of three disaccharidase in the middle part of the intestine, such as maltase, sucrase and lactase, in EH-supplemented groups were significantly lower than those of DM group. There was no significant differences in the activities of glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) among all experimental groups. Serum triglyceride in DM group was significantly increased as compared to the normal group, but those of EH-supplemented groups were decreased to the normal level. Total cholesterol level in DM group was higher than EH-supplemented groups and normal group, but that of DM-16 group was significantly decreased to the normal level. HDL cholesterol level in DM group was significantly decreased compared to the normal group, but that of EH-supplemented groups was increased to the normal level. These results suggest that enzymatic hydrolysate from Hamcho has hypoglycemic and hypolipidemic effects on STZ-induced diabetic rats and may be useful as a dietary supplement for the treatment of diabetes.


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