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함초(Salicornia herbacea)의 효소적 가수분해물이 스트렙토조토신-유발 당뇨쥐의 혈당 강하 및 혈청 지질 개선효과

Effects of Enzymatic Hydrolysates from Hamcho (Salicornia herbacea L.) on Blood Glucose and Serum Lipid Composition in Streptozotocin-Induced Diabetic Rats

  • 김경란 (대구가톨릭대학교 식품영양학과) ;
  • 최정화 (진주국제대학교 식품과학부) ;
  • 우미희 (대구가톨릭대학교 약학과) ;
  • 김영희 (양산대학 호텔조리과) ;
  • 최상원 (대구가톨릭대학교 식품영양학과)
  • Kim, Kyung-Ran (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Choi, Jeong-Hwa (School of Food Science, Jinju International University) ;
  • Woo, Mi-Hee (College of Pharmacy, Catholic University of Daegu) ;
  • Kim, Young-Hee (Dept. of Hotel Culinary Art, Yangsan College) ;
  • Choi, Sang-Won (Dept. of Food Science and Nutrition, Catholic University of Daegu)
  • 발행 : 2008.02.29

초록

본 연구에서는 STZ-유발 당뇨쥐에서 함초 효소가수분해물의 공급이 혈당 강하 및 혈청 지질 상태에 미치는 영향을 관찰하였다. STZ-유발 당뇨쥐 체중증가량은 STZ 투여군 모두가 현저하게 감소하였다. STZ-유발 당뇨쥐에서 혈중 포도당 함량은 DM군에 비해 DM-4군과 DM-8군에서 유의적(p<0.05)으로 감소하였으며, 또한 소장의 중간 부분에서 이당류 분해효소 활성을 저해하여 혈당 강하효과가 있음을 알 수 있었다. 간조직 손상의 지표를 나타내는 GOT 및 GPT 효소 활성 변화를 측정한 결과 함초 가수분해물은 유의적으로 GOT 및 GPT 활성 변화에 거의 영향을 미치지 않았다. 혈청 중의 중성지질 함량은 당뇨대조군(DM군)이 정상군에 비해 약 2배 정도 높았으나 함초 효소가수분해물 공급군에서 정상군 수준이었다. HDL-콜레스테롤 함량은 DM군에서 유의적으로 감소하였으나 함초 효소가수분해물 공급군에서 정상군 수준이었다. 총콜레스테롤 함량은 DM군에 비해 함초 효소가수분해물 공급군에서 다소 감소하는 경향이었으며, 특히 DM-16군에서 정상군 수준이었다. 이러한 결과를 미루어 볼 때 효소처리에 의해 제조된 함초 효소가수분해물의 공급은 STZ-유발 당뇨쥐에서 혈당 강하효과 및 혈청의 총지질, 중성지질, 콜레스테롤 및 HDL-콜레스테롤 등의 지질함량을 조절함으로써 지질 상태 개선효과가 있음을 알 수 있었다.

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피인용 문헌

  1. Effect of Dietary Intake of Salicornia herbacea L. Hot Water Extract on Anti-obesity in Diet-induced Obese Rats vol.41, pp.7, 2012, https://doi.org/10.3746/jkfn.2012.41.7.950
  2. Quality Characteristic of Glasswort (Salicornia herbacea L.) Fermented by Bacillus subtilis vol.38, pp.7, 2009, https://doi.org/10.3746/jkfn.2009.38.7.902